| 周妍卉,刘先军,熊 畅,王梅芳,唐以军.利福喷丁对肺结核患者血清IL-6、IFN-γ、CA125水平的影响[J].现代生物医学进展英文版,2018,(21):4118-4121. |
| 利福喷丁对肺结核患者血清IL-6、IFN-γ、CA125水平的影响 |
| Efficacy of Rifapentine in the Treatment of Tuberculosis and Its Effects on the Serum Levels of IL-6, IFN-γ and CA125 |
| Received:March 06, 2018 Revised:March 31, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.21.026 |
| 中文关键词: 肺结核 利福喷丁 利福平 抗结核治疗 |
| 英文关键词: Tuberculosis Rifapentine Rifampicin Anti tuberculosis treatment |
| 基金项目:湖北省自然科学基金项目(2010CDB09205) |
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| 中文摘要: |
| 摘要 目的：探讨利福喷丁对肺结核患者的治疗效果及对血清白介素(IL)-6、干扰素(IFN)-γ、CA125的影响。方法：选择2013年1月至2016年4月我院接诊的96例肺结核患者，通过随机数表法分为观察组(n=48)和对照组(n=48)。在常规抗结核方案基础上，对照组使用利福平，观察组使用利福喷丁。比较两组治疗前后用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、最大通气量(MVV)、血清IL-6、IFN-γ、CA125水平、临床疗效及不良反应的发生情况。结果：治疗后，观察组用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、最大通气量(MVV)、临床疗效总有效率均明显高于对照组(P＜0.05)；血清IL-6、IFN-γ、CA125水平、白细胞下降、肝功异常、皮疹、胃肠道反应发生率均显著低于对照组(P＜0.05)。结论：利福喷丁治疗肺结核的临床效果显著，可明显改善患者的肺功能，降低患者血清IL-6、IFN-γ、CA125的水平，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of rifapentine and its effect on the serum levels of interleukin(IL)-6, interferon(IFN)-γ and CA125 of patients wuth tuberculosis. Methods: 96 patients with tuberculosis who were treated in our hospital from January 2013 to April 2016 were selected and randomly divided into the observation group (n=48) and the control group (n=48). On the basis of routine anti tuberculosis scheme, the patients in the control group were treated with rifampicin, while the patients in the observation group were treated with rifapentine. Then the serum levels of IL-6, IFN-γ and CA125, the respiratory function, the clinical curative ef- fect and the adverse reactions in the two groups were observed and compared before and after the treatment. Results: After treatment, the forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximal ventilation volume (MVV) in the observation group were significantly higher than those of the control group (P<0.05). The serum levels of IL-6, IFN-γ and CA125 n the observation group were significantly lower than those of the control group (P<0.05). The total effective rate in the observation group was significantly higher than that of the control group(P<0.05). The incidence rate of leukopenia, abnormal liver function, rash and gastrointestinal reac- tions in the observation group was significantly lower than that of the control group (P<0.05). Conclusion: Rifapentine was effective for tuberculosis, which could effectively reduce the expression of serum IL-6, IFN-γ and CA125 and improve the lung function with high se- curity. |
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