| 王文涛,简百录,乔少谊,季金涛,王 磊.坦洛新对输尿管下段结石患者体外冲击波碎石术后排石及血清IL-6，IL-10和CRP水平的影响[J].现代生物医学进展英文版,2018,(21):4099-4102. |
| 坦洛新对输尿管下段结石患者体外冲击波碎石术后排石及血清IL-6，IL-10和CRP水平的影响 |
| Effect of Tamsulosin on the Patients with Lower Ureteral Stones after Extracorporeal Shock Wave Lithotripsy and Serum Levels of IL-6, IL-10 and CRP |
| Received:February 26, 2018 Revised:March 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.21.021 |
| 中文关键词: 坦洛新 输尿管下段结石 体外冲击波碎石术 辅助排石 白细胞介素-6 白细胞介素-10 C反应蛋白 |
| 英文关键词: Tamsulosin Lower ureteral stones Extracorporeal shock wave lithotripsy Auxiliary row stone Interleukin -6 Inter- leukin -10 C reactive protein |
| 基金项目:陕西省自然科学基金项目(25K3687) |
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| 中文摘要: |
| 摘要 目的：探讨输尿管下段结石行体外冲击波碎石术(ESWL)后应用坦洛新辅助排石的临床效果及对患者血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、C反应蛋白(CRP)水平的影响。方法：选取我院2015年1月~2016年12月收治的122例输尿管下段结石患者，采用随机数字表法均分为两组。于ESWL术后，对照组给予硝苯地平治疗，观察组予以坦洛新治疗。记录比较两组术后排石效果、疼痛情况，治疗前后血清IL-6、IL-10和CRP水平的变化及不良反应的发生情况。结果：治疗后，观察组无石率(91.8%)明显高于对照组(78.7%) (P<0.05)；观察组排石时间短于对照组，排石直径大于对照组(P<0.05)；观察组患者血清IL-6，IL-10及CRP水平均显著低于对照组(P<0.05)。与对照组相比，观察组肾绞痛发生率、镇痛剂使用率及VAS评分均较低(P<0.01)。用药期间，两组均未发生明显不良反应（P>0.05）。结论：坦洛新能有效提高输尿管下段结石患者体外冲击波碎石术的排石效果，减轻机体损伤，缓解术后疼痛，并且安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of tamsulosin on the extracorporeal shock wave lithotripsy (ESWL) of patients with ureteral calculi and the serum levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and C-reactive protein (CRP). Methods: 122 cases with lower ureteral stones who were treated in our hospital from January 2015 to December 2016 were selected and randomly divide into two groups. After ESWL, the patients in the control group were treated with nifedipine, while the patients in the observation group were treated with tamsulosin. Then the postoperative row of stones, the pain, the serum levels of IL-6, IL-10 and CRP and the incidence of ad- verse reactions in the two groups before and after the treatment. Results: After treatment, the stone free rate of the observation group was 91.8%, which was significant higher than 78.7% in the control group (P<0.05). The time of row stone and the diameter of stone row in the observation group were significantly better than those of the control group (P<0.05). The incidence of renal colic, analgesic use and VAS score in the observation group were significantly lower than those of the control group (P<0.01). The serum inflammatory cytokine levels in the observation group were significantly lower than those of the control group (P<0.01). There was no statistically significant difference about the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Tamsulosin could improve the row stone effectively for patients with lower ureteral stones after ESWL, reduce the operation injury and relieve the postoperative pain. |
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