| 徐梅佳,刘英丽,董 焱,路黎娟,吕 伟.茵栀黄颗粒联合蓝光治疗新生儿病理性黄疸的疗效及对患儿心肌酶谱的影响[J].现代生物医学进展英文版,2018,(21):4046-4050. |
| 茵栀黄颗粒联合蓝光治疗新生儿病理性黄疸的疗效及对患儿心肌酶谱的影响 |
| Clinical Effect of Yinzhihuang Granules Combined with Blue Light Treatment on Neonatal Pathological Jaundice and Influence on the Serum Muscle Enzyme Spectrum |
| Received:March 28, 2018 Revised:April 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.21.009 |
| 中文关键词: 茵栀黄颗粒 新生儿病理性黄疸 疗效 心肌酶谱 |
| 英文关键词: Yinzhihuang Granules Neonatal jaundice Curative effect Myocardial enzymes |
| 基金项目:上海市自然科学基金项目(15ZA1234292) |
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| 中文摘要: |
| 摘要 目的：探讨茵栀黄颗粒联合蓝光治疗新生儿病理性黄疸的疗效及对患儿心肌酶谱的影响。方法：选取2015年2月至2016年12月于我院就诊的80例新生儿病理性黄疸患儿，随机分为观察组和对照组，每组各40例。根据两组患儿的临床症状有针对性地给予常规治疗，对照组在此基础上加用蓝光照射治疗，观察组加用蓝光照射联合茵栀黄颗粒进行治疗，两组均持续治疗一个星期。比较两组的临床疗效、治疗前后血清心肌酶、胆红素水平的变化以及不良反应的发生情况。结果：治疗前，两组患儿的血清总胆红素(TBIL)、直接胆红素(DBIL)水平比较差异不明显(P>0.05)；治疗后，两组TBIL、DBIL水平均较同组治疗前显著降低(P<0.05)，且观察组显著低于对照组，差异有统计学意义(P<0.05)。治疗前，两组患儿血清乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)水平比较差异不显著(P>0.05)；治疗后，两组血清LDH、CK、CK-MB水平均较同组治疗前显著降低(P<0.05)，且观察组显著低于对照组，差异有统计学意义(P<0.05)。治疗后，两组不良反应的发生情况比较差异无统计学意义(P>0.05)。结论：茵栀黄颗粒联合蓝光照射治疗新生儿黄疸较单用蓝光照射治疗可显著提高临床疗效，显著改善患儿血清胆红素及心肌酶谱水平，且安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical efficacy of Yinzhihuang granules combined with blue light in the treatment of neonatal pathological jaundice and the effect on myocardial enzymes. Methods: 80 cases of patients with neonatal pathological jaundice treated in our hospital from February 2015 to December 2016 were randomly divided into two groups (control group and observation group), with 40 cases in each group. All patients were given routine treatment according to the clinical symptoms, and patients in control group were treated with blue light irradiation. Patients in the observation group were treated with Yinzhihuang granules combined with blue light irradiation. Both groups were treated continuously for one week. The clinical efficacy, serum myocardial enzymes, bilirubin levels and incidence of adverse reactions of two groups were compared. Results: Before treatment, there was no significant difference in the serum total bilirubin (TBIL) and direct bilirubin (DBIL) levels between the two groups (P>0.05). After treatment, the levels of serum bilirubin in both groups were both significantly decreased (P<0.05), and the TBIL and DBIL levels in the observation group were signifi- cantly lower than those in the control group. Before treatment, there was no significant difference in the serum lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) between the two groups (P>0.05). After treatment, the levels of myocardial enzymes of both groups were significantly decreased (P<0.05), and the LDH, CK and CK-MB levels in observation group were significantly lower than those of the control group (P<0.05). After treatment, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Yinzhihuang granules combined with blue light can significantly im- prove the clinical efficacy, the serum bilirubin, the myocardial enzyme spectrum, and is more secure in the treatment of neonatal jaundice compared with the treatment of blue light irradiation alone. |
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