| 任晓兵,钟 勇,陈广福,王文娟,高 娟.弥漫性轴索损伤患者血清MBP、IL-1β、IL-8及TNF-α水平的表达及临床意义[J].现代生物医学进展英文版,2018,(20):3972-3975. |
| 弥漫性轴索损伤患者血清MBP、IL-1β、IL-8及TNF-α水平的表达及临床意义 |
| Expression and Clinical Significance of Serum MBP, IL-1β, IL-8 and TNF-α Levels in Patients with Diffuse Axonal Injury |
| Received:May 14, 2018 Revised:June 12, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.20.039 |
| 中文关键词: 弥漫性轴索损伤 髓鞘碱性蛋白 白细胞介素-1β 白细胞介素-8 肿瘤坏死因子-α |
| 英文关键词: Diffuse axonal injury Myelin basic protein Interleukin-1β Interleukin-8 Tumor necrosis factor-α |
| 基金项目:陕西省自然科学基金项目(2014JM1369) |
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| 中文摘要: |
| 摘要 目的：探讨弥漫性轴索损伤（DAI）患者血清髓鞘碱性蛋白（MBP）、白细胞介素-1β（IL-1β）、白细胞介素-8（IL-8）及肿瘤坏死因子-α（TNF-α）水平的表达及临床意义。方法：选取2015年12月-2018年1月我院神经外科收治的DAI患者90例作为观察组，另选取在我院体检的健康志愿者30例作为对照组，并根据格拉斯哥昏迷评分（GCS）将观察组患者分为重度组（42例）、中度组（30例）、轻度组（18例）。对比观察组和对照组血清MBP、IL-1β、IL-8及TNF-α水平，比较观察组患者不同严重程度、伤后不同时间血清MBP、IL-1β、IL-8及TNF-α水平。结果：观察组患者血清中的MBP、IL-1β、IL-8及TNF-α水平显著高于对照组（P<0.05）。重度组患者血清MBP、IL-1β、IL-8及TNF-α水平显著高于中度组和轻度组，且中度组显著高于轻度组（P<0.05）。伤后不同时间观察组患者血清MBP、IL-1β、IL-8及TNF-α水平整体比较差异均有统计学意义（P<0.05）；其中MBP水平在伤后前期到伤后3d持续升高（P<0.05）；IL-1β、IL-8、TNF-α水平在伤后前期到伤后2d持续升高，在伤后3d呈下降趋势（P<0.05）。结论：DAI患者血清MBP、IL-1β、IL-8及TNF-α水平偏高，临床通过检测这四种血清指标水平，有助于评估患者的病情。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of serum myelin basic protein (MBP), interleukin -1β(IL-1β), interleukin -8 (IL-8) and tumor necrosis factor -α (TNF-α) in patients with diffuse axonal injury(DAI) and its clinical significance. Methods: A total of 90 patients with DAI, who were admitted to Department of neurosurgery in Xi'an Gaoxin Hospital from December 2015 to January 2018, were selected as observation group; another 30 healthy volunteers, whose physical examination results were normal, as control group. The patients in the observation group were again divided into severe group (n=42), moderate group (n=30) and mild group (n=18) according to the Glasgow coma scale (GCS). The levels of serum MBP, IL-1β, IL-8 and TNF-α were compared between the observation group and the control group. The levels of serum MBP, IL-1β, IL-8 and TNF-α of patients in the observation group with different severity and time were compared. Results: The levels of serum MBP, IL-1β, IL-8 and TNF-α in the observation group were significantly higher than those in the control group(P<0.05). The levels of serum MBP, IL-1β, IL-8 and TNF-α in the severe group were significantly higher than those in the moderate group and the mild group, and the moderate group was significantly higher than the mild group(P<0.05). The levels of serum MBP, IL-1β, IL-8 and TNF-α in the observation group were statistically significant at different time after injury(P<0.05), in which, the level of MBP remained elevated from the early stage after injury to 3d after injury (P<0.05); the levels of IL-1β, IL-8, TNF-α remained elevated from the early stage after injury to 2d after injury, decreasing 3d after injury(P<0.05). Conclusion: The levels of serum MBP, IL-1β, IL-8 and TNF-α are higher in DAI patients. The clinical detection of these four serum markers can help doctors assess the conditions of the patients. |
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