| 李玉平,王术凤,梁学军,刘佰洁,陈洪学.黄芪丹参颗粒治疗慢性肾功能衰竭患者的临床疗效分析[J].现代生物医学进展英文版,2018,(20):3925-3928. |
| 黄芪丹参颗粒治疗慢性肾功能衰竭患者的临床疗效分析 |
| Clinical Effect of Radix Astragali and Radix Salviae Miltiorrhizae on the Chronic Renal Failure |
| Received:June 03, 2018 Revised:June 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.20.028 |
| 中文关键词: 黄芪丹参颗粒 慢性肾脏衰竭 肾功能试验 临床疗效 |
| 英文关键词: Radix Astragali and Radix Salviae Miltiorrhizae Chronic Renal Failure Renal function test |
| 基金项目:广东省佛山市科技局项目(2015AB00328) |
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| 中文摘要: |
| 摘要 目的：探讨黄芪丹参颗粒治疗慢性肾衰患者的临床效果，为慢性肾衰患者的临床治疗提供参考。方法：选择本院2016年1月至2017年12月收治的160例慢性肾衰患者，根据其治疗方式分为两组。对照组给予常规药物治疗，治疗组在常规药物治疗的基础上给予黄芪丹参颗粒治疗。观察比较两组患者治疗前后肾功能、急性生理与慢性健康评分(APACHE Ⅱ)和简化急性生理评分(SAPS Ⅱ)以及生活质量的变化。结果：治疗后，治疗组血尿素氮(BUN)、血肌酐(SCr)、尿蛋白和尿微量蛋白水平、APACHE Ⅱ和SAPS Ⅱ评分均显著低于对照组，肾小球滤过率(GFR)水和生活质量评分均明显高于对照组(P＜0.05)。结论：黄芪丹参颗粒治疗慢性肾衰患者可明显改善患者的肾功能，提高患者生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the therapeutic effect and mechanism of Huangqi Danshen granule on patients with chronic renal failure and provide references for the clinical treatment of patients with chronic renal failure. Methods: 160 cases of patients with chronic renal failure treated in our hospital from January 2016 to December 2017 were selected. They were divided into two groups according to the treatment method, the routine group was given routine drug therapy, the experimental group was treated with Huangqi Danshen granule on the basis of routine drug therapy. The changes of renal function, acute physiological and chronic health score (Apache Ⅱ), simplified acute physiological score (SAPS Ⅱ) and quality of life were observed and compared between the two groups before and after treatment. Results: After treatment, the blood urea nitrogen (BUN), serum creatinine (SCr), urine protein and urine microprotein level, APACHE II and SAPS II score were significantly lower than those in the control group, and the glomerular filtration rate (GFR) and the quality of life score were significantly higher than those in the control group (P<0.05). Conclusion: Huangqi Danshen granule had better therapeutic effect on the patients with chronic renal failure. It culd obviously improve the renal function and the quality of life of patients. |
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