| 韩俊凤,冯 雨,姜 冰,董 雪,张 强.酮替芬联合沙丁胺醇气雾剂喷吸对咳嗽变异性哮喘患者嗜酸性粒细胞趋化因子与肺功能的影响[J].现代生物医学进展英文版,2018,(20):3917-3921. |
| 酮替芬联合沙丁胺醇气雾剂喷吸对咳嗽变异性哮喘患者嗜酸性粒细胞趋化因子与肺功能的影响 |
| Effect of Ketotifen Combined with Salbutamol Aerosol Spraying on Eotaxin and Pulmonary Function in Cough Variant Asthma Patients |
| Received:April 25, 2018 Revised:May 21, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.20.026 |
| 中文关键词: 咳嗽变异性哮喘 酮替芬 沙丁胺醇 嗜酸性粒细胞趋化因子 肺功能 |
| 英文关键词: Cough variant asthma Ketotifen Salbutamol Eotaxin Pulmonary function |
| 基金项目:辽宁省自然科学基金项目（20120453） |
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| 中文摘要: |
| 摘要 目的：探讨酮替芬联合沙丁胺醇气雾剂喷吸对咳嗽变异性哮喘患者嗜酸性粒细胞趋化因子与肺功能的影响。方法：选择2015年3月到2016年4月我院接诊的98例咳嗽变异性哮喘患者研究，按抽签法将其随机分为观察组和对照组，每组49例。对照组患者给予沙丁胺醇气雾剂、氨茶碱治疗，观察组在对照组基础上给予酮替芬治疗。观察比较治疗前后两组临床疗效；白天及夜间咳嗽症状评分；嗜酸性粒细胞（EOS）计数和嗜酸性粒细胞趋化因子（Eotaxin）水平；肺功能相关评价指标（FVC、FEV1、PEF）。结果：治疗后，观察组有效率（93.88%）高于对照组（79.59%），差异有统计学意义（P<0.05）。两组白天及夜间咳嗽症状评分均显著下降，观察组下降更为明显[（0.77±0.39）VS（0.99±0.52）、（0.87±0.32）VS（1.07±0.34）]，差异有统计学意义（P<0.05）；两组EOS计数和Eotaxin水平均明显下降，观察组下降更为显著[（188.47±30.39）VS（232.59±30.52）、（169.44±27.79）VS（191.07±34.34）]，差异具有统计学意义（P<0.05）；两组相关评价指标（FVC、FEV1、PEF）均明显提高，观察组相关指标值提高更为显著[（3.99±0.39）VS（3.87±0.12）、（3.87±0.79）VS（3.52±0.39）、（7.99±1.98）VS（7.34±1.01）]，差异有统计学意义（P<0.05）。结论：酮替芬联合沙丁胺醇气雾剂喷吸对咳嗽变异性哮喘的疗效显著，能明显降低患者嗜酸性粒细胞趋化因子的水平，显著改善患者的肺功能，值得临床推广运用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of ketotifen and salbutamol aerosol on eosinophil and lung function in patients with cough variant asthma. Methods: A total of 98 cough variant asthma patients admitted to our hospital from March 2015 to April 2016 were randomly divided into observation group and control group according to random sampling method, with 49 cases in each group. Patients in the control group were given albuterol aerosol and aminophylline, and the observation group was given ketotifen on the basis of the control group. The clinical curative effect was observed and compared between the two groups before and after treatment. The scores of cough symptom at daytime and nighttime, the eosinophil count (EOS) and Eotaxin level, and the pulmonary function related evaluation index (FVC, FEV1, PEF) were observed. Results: After treatment, the effective rate of the observation group (93.88%) was higher than that of the control group (79.59%), the difference was statistically significant (P <0.05). The cough symptom scores of both groups were significantly decreased during the day and night, and the decrease in the observation group was more significant[(0.77 ± 0.39) vs (0.99 ± 0.52), ( 0.87 ± 0.32) vs( 1.07 ± 0.34)], respectively(P <0.05). The EOS counts and Eotaxin levels in both groups were significantly decreased, and the decrease in the observation group was more significant [(188.47 ± 30.39 )vs( 232.59 ± 30.52), (169.44 ± 27.79) vs( 191.07 ± 34.34)] , respectively (P <0.05). The relative indexes (FVC, FEV1, PEF) in both groups were significantly higher than those in the control group [(3.99 ± 0.39 )vs( 3.87 ± 0.12), (3.87 ± 0.79) vs 3.52 ± 0.39, (7.99 ± 1.98) VS (7.34 ± 1.01)], the difference was statistically significant (P <0.05). Conclusion: Ketotifen combined with salbutamol aerosol spray has no significant effect on cough variant asthma Significant effect, can significantly reduce the level of eotaxin in patients with significant improvement in patients with lung function, it is worth promoting clinical application. |
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