| 蔡新宇,程 绩,苏 晴,江 利,周人杰.急性心肌梗死患者血浆BNP、NT-proBNP、MYO及cTnI水平的表达及临床意义[J].现代生物医学进展英文版,2018,(20):3866-3869. |
| 急性心肌梗死患者血浆BNP、NT-proBNP、MYO及cTnI水平的表达及临床意义 |
| The Expression Levels and Clinical Significance of Plasma BNP, NT-proBNP, MYO and cTnI in Patients with Acute Myocardial Infarction |
| Received:February 04, 2018 Revised:February 28, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.20.014 |
| 中文关键词: 急性心肌梗死 B型利钠肽 N-末端B型利钠肽原 肌红蛋白 心肌肌钙蛋白I |
| 英文关键词: Acute myocardial infarction B-type natriuretic peptide N-terminal B-type natriuretic peptide Myoglobin Cardiac troponin |
| 基金项目:重庆市医学科研基金项目（2011A0210063） |
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| 中文摘要: |
| 摘要 目的：探讨急性心肌梗死患者血浆B型利钠肽（BNP）、N-末端B型利钠肽原（NT-proBNP）、肌红蛋白（MYO）及心肌肌钙蛋白I（cTnI）的表达及临床意义。方法：选择2015年8月至2016年8月我院收治的162例急性心肌梗死患者记为观察组，另选择162例同期于我院健康体检志愿者为对照组进行对比研究。应用免疫分离法检测两组血浆BNP、NT-proBNP、MYO及cTnI水平。对比两组血浆BNP、NT-proBNP、MYO及cTnI的表达水平，以及BNP、NT-proBNP、MYO、cTnI单独检测和联合检测在急性心肌梗死诊断中的灵敏度及特异性，并分析各指标之间的相关性。结果：观察组血浆BNP、NT-proBNP、MYO及cTnI水平均高于对照组，差异有统计学意义（P<0.05）。四项联合检测的灵敏度分别高于血浆BNP、NT-proBNP、MYO及cTnI单独检测，特异性分别高于血浆NT-proBNP、MYO单独检测，差异有统计学意义（P<0.05），四项联合检测的特异性分别高于血浆BNP、cTnI单独检测，但差异无统计学意义（P>0.05）。通过Spearman相关性分析显示，观察组血浆BNP、NT-proBNP、MYO及cTnI各指标水平之间呈正相关（P<0.05）。结论：血浆BNP、NT-proBNP、MYO及cTnI在急性心肌梗死中具有明显高表达，且四项联合检测的灵敏度及特异性较高，各指标之间存在正相关关系，可为急性心肌梗死早期诊断提供科学的依据，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of plasma B type natriuretic peptide (BNP), N-terminal B type natriuretic peptide (NT-proBNP), myoglobin (MYO) and cardiac troponin I (cTnI) in patients with acute myocardial infarction. Methods: 162 patients with acute myocardial infarction who were admitted in our hospital from August 2015 to August 2016 were selected as the observation group. In addition, 162 healthy volunteers in our hospital at the same time were selected as the control group for comparison study. The levels of plasma BNP, NT-proBNP, MYO and cTnI in two groups were detected by immuno isolation.The expression levels of plasma BNP, NT-proBNP, MYO and cTnI were compared in two groups, the sensitivity and specificity of BNP,NT-proBNP, MYO and cTnI separate detection and combined detection in the diagnosis of acute myocardial infarction were compared,and the correlation between the indexes was analyzed. Results: The levels of plasma BNP, NT-proBNP, MYO and cTnI in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The sensitivity of combined detection of four was higher than that of plasma BNP, NT-proBNP, MYO and cTnI respectively, the specificity was higher than that of plasma NT-proBNP, MYO respectively, the difference was statistically significant(P<0.05). The specificity of combined detection of four was higher than that of plasma BNP, cTnI respectively, but the difference was not statistically significant(P>0.05). The Spearman correlation analysis showed that there was a positive correlation between the levels of plasma BNP, NT-proBNP, MYO and cTnI in the observation group (P<0.05). Conclusion: The levels of plasma BNP, NT-proBNP, MYO and cTnI are highly expressed in patients with acute myocardial infarction, the sensitivity and specificity of combined detection of four are high, there is a positive correlation between the indexes, and it can provide scientific basis for early diagnosis of acute myocardial infarction, which is worthy of clinical popularization. |
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