| 侯慧艳,张剑蔚,顾洪斌,宋蕴安,白 洁.单纯右美托咪定滴鼻与水合氯醛复合右美托咪定滴鼻在脑瘫患儿MRI检查中的应用效果比较[J].现代生物医学进展英文版,2018,(20):3858-3861. |
| 单纯右美托咪定滴鼻与水合氯醛复合右美托咪定滴鼻在脑瘫患儿MRI检查中的应用效果比较 |
| Comparison of the Effect of Intranasal Dexmedetomidine Combined with Chloral Hydrate and Dexmedetomidine Nasal Drops on the MRI Examination of Children with Cerebral Palsy |
| Received:February 28, 2018 Revised:March 25, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.20.012 |
| 中文关键词: 右美托咪定 水合氯醛 脑瘫 MRI |
| 英文关键词: Dexmedetomidine Chloral hydrate Cerebral palsy MRI |
| 基金项目:上海交通大学医学院附属上海儿童医学中心基金项目（YJ-SCMC2017-4） |
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| 中文摘要: |
| 摘要 目的：比较单纯右美托咪定滴鼻与水合氯醛复合右美托咪定滴鼻在脑瘫患儿核磁共振成像(MRI)检查中的应用效果。方法：收集我院2015年1月到2016年7月收治的160例脑瘫患儿，按照就诊号排序后取随机数字分为单纯组和复合组，每组各80例。单纯组给予右美托咪定2 μg/kg滴鼻+生理盐水口服(0.1 mL/kg)，复合组给予口服水合氯醛50 mg/kg+右美托咪定(2 μg/kg)滴鼻，采用密歇根大学小儿镇静评分(UMSS)评价镇静效果、镇静成功率，检测和比较两组患儿给药前后心率(HR)、血氧饱和度(SpO2)、呼吸频率(RR)及入睡时间、苏醒时间、检查时间与父母分离时间等。结果：给药前，两组UMSS评分比较差异无统计学意义(P>0.05)，给药15 min、30 min，复合组UMSS评分明显高于单纯组(P<0.05)；给药30 min时，复合组镇静成功率为98.8%，单纯组为91.3%，差异具有统计学意义(P<0.05)；两组给药前后HR、SpO2、RR水平比较差异均无统计学意义(P>0.05)。单纯组入睡、苏醒、检查时间及与父母分离时间长于复合组(P<0.05)。结论：水合氯醛复合右美托咪定滴鼻在脑瘫患儿MRI检查中的镇静效果明显优于单纯右美托咪定滴鼻。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effect of intranasal dexmedetomidine and chloral hydrate combined with dexmedetomidine on the MRI Examination of children with cerebral palsy. Methods: 160 cases of cerebral palsy were collected in our hospital from January 2015 to July 2016 and divided into the simple group and the complex group according to the number of visits sorted random numbers, 80 cases in each group. The simple group was given Dexmedetomidine 2 μg/kg+saline nasal oral(0.1 mL/kg), the compound group was given oral chloral hydrate 50 mg/kg+ dexmedetomidine (2μ g/kg) by nasal drip, University of Michigan pediatric sedation score (UMSS) was used to evaluate the effect and success rate of sedation, the heart rate (HR), oxygen saturation (SpO2), respiratory rate (RR) before and after administration, sleep time, recovery time, check time and separation time with parents were compared between the two groups. Results: Before administration, no significant difference was found in the UMSS score between two groups(P>0.05), at 15min and 30 min after administration, the UMSS score of complex group were significantly higher than those of simple group(P<0.05); at 30min after administration, the success rate of sedation in complex group was 98.8%, which was 91.3% in the simple group and obviously lower than that of the complex group(P<0.05); no statistical difference was found in the HR, SpO2, RR before and after administration(P>0.05). The sleep, recovery, examination time and separation time of simple group were longer than those of the complex group(P<0.05). Conclusion: Chloral hydrate combined with dexmedetomidine nasal drops showed better sedative effect on the MRI examination of children with cerebral palsy than simple dexmedetomidine nasal drops. |
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