| 宋桂仙,阮中宝,朱 莉,王如珠,李建民,林 杰.慢性心力衰竭患者彩色多普勒超声心功能参数与血清同型半胱氨酸水平的相关性研究[J].现代生物医学进展英文版,2018,(19):3653-3656. |
| 慢性心力衰竭患者彩色多普勒超声心功能参数与血清同型半胱氨酸水平的相关性研究 |
| Correlation between Cardiac Function Parameters of Color Doppler Ultrasound and Serum Homocysteine Level in Patients with Chronic Heart Failure |
| Received:April 27, 2018 Revised:May 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.19.011 |
| 中文关键词: 慢性心力衰竭 彩色多普勒超声 心功能 同型半胱氨酸 相关性 |
| 英文关键词: Chronic heart failure Color doppler ultrasound Cardiac function Homocysteine Correlation |
| 基金项目:国家自然科学基金项目（81600223） |
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| 中文摘要: |
| 摘要 目的：探讨慢性心力衰竭（CHF）患者彩色多普勒超声的心功能参数与血清同型半胱氨酸水平的相关性。方法：选取2016年2月至2017年6月期间我院收治的CHF患者73例作为研究组，选取同期体检的健康志愿者70例作为对照组。检测两组血清同型半胱氨酸（Hcy）及氨基末端B型利钠肽前体（NT-proBNP）水平，采用彩色多普勒超声测定两组心脏左室射血分数（LVEF）及左室舒张末期内径（LVEDd）。分析CHF患者血清Hcy水平与NT-proBNP、LVEF、LVEDd的相关性，观察不同血清Hcy水平CHF患者心血管事件发生情况。结果：研究组血清Hcy、NT-proBNP及LVEDd显著高于对照组，LVEF显著低于对照组（P<0.05）。IV级患者血清Hcy、NT-proBNP、LVEDd水平高于II级与III级，且III级高于II级（P<0.05）；IV级患者LVEF水平低于II级与III级，且III级低于II级（P<0.05）。由Pearson相关性分析可得，CHF患者血清Hcy水平与血清NT-proBNP、LVEDd呈正相关，与LVEF呈负相关（P<0.05）。血清Hcy水平高于25 μmol/L的患者心血管事件发生率为31.43%，血清Hcy水平在15 μmol/L-25 μmol/L范围内的患者心血管事件发生率为10.53%，差异有统计学意义（P<0.05）。结论：CHF患者血清Hcy、NT-proBNP、LVEDd随心功能恶化程度增加而升高，LVEF随之降低，且Hcy水平越高，患者预后越差。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between cardiac function parameters of color Doppler ultrasound and serum homocysteine level in patients with chronic heart failure (CHF). Methods: 73 patients with CHF who were treated in our hospital from February 2016 to June 2017 were selected as the study group, and 70 healthy volunteers in the same period were selected as the control group. The levels of serum homocysteine (Hcy) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in two groups were detected, left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDd) in two groups were measured by color Doppler ultrasound. The correlation between serum Hcy level and NT-proBNP, LVEF and LVEDd in patients with CHF was analyzed, the occurrence of cardiovascular events in CHF patients with different serum Hcy levels was observed. Results: The serum levels of Hcy, NT-proBNP and LVEDd in the study group were significantly higher than those in the control group, and the LVEF was significantly lower than that of the control group (P<0.05). The level of serum Hcy, NT-proBNP and LVEDd in patients with IV grade was higher than that of II grade and III grade, and the level of III grade was higher than that of II grade(P<0.05). The level of LVEF in patients with IV grade was lower than that of II grade and III grade, and the level of III grade was lower than that of II grade(P<0.05). Pearson correlation analysis showed that the level of serum Hcy in patients with CHF was positively correlated with serum NT-proBNP and LVEDd, and it was negatively correlated with LVEF(P<0.05). The incidence of cardiovascular events in patients with serum Hcy level above 25 μmol/L was 31.43%, and the incidence of cardiovascular events in patients with the serum Hcy level in 15 μmol/L-25 μmol/L was 10.53%, the difference was statistically significant(P<0.05). Conclusion: The serum levels of Hcy, NT-proBNP, and LVEDd in patients with CHF is increased with the increase of the severity of cardiac function deterioration, and the LVEF is decreasing. The level of serum Hcy is posi- tively correlated with serum NT-proBNP and LVEDd, and the higher the Hcy level, the worse the patient's prognosis. |
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