| 邓立功,余益君,程 倬,张 莉,祁家全.乌司他丁联合前列地尔对急性胰腺炎的临床疗效及对血清TNF-α、IL-1β、HMGB1、HSP的影响[J].现代生物医学进展英文版,2018,(18):3554-3557. |
| 乌司他丁联合前列地尔对急性胰腺炎的临床疗效及对血清TNF-α、IL-1β、HMGB1、HSP的影响 |
| Clinical Efficacy of Ulinastatin Combined with Prostadil in Treatment of Acute Pancreatitis and Effects on Serum TNF-α, IL-1β, HMGB1 and HSP Levels |
| Received:June 13, 2017 Revised:July 07, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.18.035 |
| 中文关键词: 乌司他丁 前列地尔 急性胰腺炎 肿瘤坏死因子-α 白细胞介素1β 高迁移率组蛋白1 热休克蛋白 |
| 英文关键词: Ulinastatin Algae Acute pancreatitis TNF-α IL-1β HMGB1 HSP |
| 基金项目:四川省卫生厅科研基金项目(120027) |
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| 中文摘要: |
| 摘要 目的：探讨乌司他丁联合前列地尔治疗急性胰腺炎的临床疗效及对血清肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)、白细胞介素(Interleukin-1 beta，IL-1β)、高迁移率组蛋白1(HMGB1)、热休克蛋白(HSP)的影响。方法：选择72例我院收治的急性胰腺炎患者并将其随机平均分为观察组和对照组。对照组按照常规方法治疗，观察组在常规治疗方法上采用乌司他丁联合前列地尔加入葡萄糖注射治疗。比较两组患者临床症状及体征恢复时间、治疗前后血清TNF-α、IL-1β、HMGB1、HSP水平的变化及血淀粉酶水平的恢复情况。结果：治疗后，观察组的总有效率为97.2%，对照组的总有效率为69.7%，观察组显著高于对照组(P<0.05)；观察组多个体征恢复时间均明显短于对照组(P<0.05)；两组血清TNF-α、IL-1β、HMGB1、HSP水平均较治疗前明显下降，且观察组以上指标均显著低于对照组(P<0.05)；观察组血淀粉酶水平恢复率明显高于对照组(P<0.05)。结论：乌司他丁联合前列地尔治疗急性胰腺炎能有效提高其临床疗效，显著缩短临床症状及体征恢复时间、血淀粉酶恢复时间，降低患者血清TNF-α、IL-1β、HMGB1、HSP水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of ulinastatin combined with alprostadil in the treatment of acute pancre- atitis and the effect on serum tumor necrosis factor-α (TNF-α), interleukin-1 beta IL-1β), high mobility grouping histone 1 (HMGB1) and heat shock protein (HSP). Methods: 72 patients with acute pancreatitis were randomly divided into the observation group and the control group. The control group was treated according to the conventional method. The observation group was treated with ulinastatin combined with alprostadil plus glucose injection based on the conventional treatment. The changes of serum TNF-α, IL-1β, HMGB1 and HSP lev- els and the recovery of serum amylase levels before and after treatment were observed and compared between two groups. Results: After treatment, the total effective rate was 97.2% in the observation group and 69.7% in the control group, which was signifi- cantly higher in the observation group than that of the control group(P<0.05); the recovery time of multiple signs of observation group was significantly shorter than that of the control group(P<0.05). The levels of serum TNF-α, IL-1β, HMGB1 and HSP in observation group were signifi- cantly lower than those in the control group(P<0.05). The recovery rate of enzyme level was significantly higher than that of the control group (P <0.05). Conclusion: Ulinastatin combined with alprostadil can effectively improve the clinical efficacy in the treatment of acute pancreatitis, significantly shorten the recovery time of clinical symptoms and signs as well as serum amylase, reduce the serum TNF-α, IL-1β, HMGB1, HSP Levels. |
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