| 李雅莉,张 波,黄建玲,李智敏,金 鑫.腹膜透析治疗对先天性心脏病患儿术后血清因子水平及预后的影响[J].现代生物医学进展英文版,2018,(18):3514-3517. |
| 腹膜透析治疗对先天性心脏病患儿术后血清因子水平及预后的影响 |
| Clinical Efficacy of Peritoneal Dialysis in Treatment of Congenital Heart Disease in Children and Influence on Serum Factors |
| Received:March 05, 2018 Revised:March 28, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.18.025 |
| 中文关键词: 小儿 先天性心脏病 术后腹膜透析 临床疗效 血清因子 |
| 英文关键词: Children Congenital heart disease Postoperative peritoneal dialysis Clinical curative effect Serum factor |
| 基金项目:陕西省科技攻关项目资助(2007K13-03) |
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| 中文摘要: |
| 摘要 目的：探讨腹膜透析治疗对先天性心脏病患儿术后血清因子水平及预后的影响。方法：选择2013年11月~2016年11月我院收治的96例小儿先天性心脏病，按治疗方式分为对照组与研究组，每组48例，两组均接受手术治疗。对照组于术后采用常规治疗，研究组在常规治疗基础上加以腹膜透析治疗，观察并比较两组治疗前后血清β2微球蛋白、24 h尿蛋白、血尿素氮、血肌酐、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、碳酸氢盐、钙离子、钾离子水平的变化及死亡情况。结果：治疗后，两组血清β2微球蛋白、24 h尿蛋白、血尿素氮、血肌酐、IL-6、IL-8、TNF-α、钾离子水平均较治疗前显著降低，且研究组以上指标均明显低于对照组；两组碳酸氢盐、钙离子水平均较治疗前明显上升，且研究组以上指标明显高于对照组(P<0.05)。此外，研究组死亡率明显低于对照组(P<0.05)。结论：腹膜透析治疗先天性心脏病患儿术后能够降低病死率，改善肾功能、炎症因子及电解质平衡紊乱。 |
| 英文摘要: |
| ABSTRACT Objective: To research the effect of peritoneal dialysis on the serum factors and prognosis of children with congenital heart diseas. Methods: 96 children with congenital heart disease from November 2013 to November 2016 were divided into the control group and the research group according to the treatment mode, with 48 cases in each group. Both groups were treated with surgery, the control group was treated with routine treatment after surgery, while the research group was treated with peritoneal dialysis based on the control group. The serum β2-microglobulin, 24 h urine protein, blood urea nitrogen, blood creatinine, interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-α(TNF-α), hydrocarbonate, calcium, potassium levels and mortality were observed and compared between two group. Results: After treatment, the serum β2-microglobulin, 24 h urine protein, blood urea nitrogen, blood creatinine, IL-6, IL-8, TNF-α, potassium levels of two group were decreased, which were obviously lower in the research group than those of the control group, the bicarbonate, calcium ions of two group were obviously increased, which were significantly higher in the research group than those of the control group(P<0.05). The mortality rate of research group was lower than that of the control group(P<0.05). Conclusion: Peritoneal dialysis can decrease the mortality of congenital heart disease children after operation, which regulate the serum factors, improve the kid- ney function, inflammation factor and electrolyte balance disorder. |
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