| 龚华平,李 威,宋文荣,晏益民,赵 涛.甲状腺功能亢进性心脏病患者血清BNP及CRP水平及其与心功能的关系[J].现代生物医学进展英文版,2018,(18):3498-3501. |
| 甲状腺功能亢进性心脏病患者血清BNP及CRP水平及其与心功能的关系 |
| Serum BNP and CRP Levels in the Patients with Hyperthyroid Heart Disease and Their Correlation with the Cardiac Function |
| Received:April 07, 2018 Revised:April 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.18.021 |
| 中文关键词: 甲状腺功能亢进症 甲亢性心脏病 B型尿钠肽 C反应蛋白 |
| 英文关键词: Hyperthyroidism Hyperthyroid heart disease BNP CRP. |
| 基金项目:湖北省自然科学基金项目(2010HL053) |
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| 中文摘要: |
| 摘要 目的：研究甲亢性心脏病患者血清BNP(B-type natriuretic peptide)与CRP(C-reaction protein)水平及其与心功能的关系。方法：选择2015年10月至2017年3月在我院进行治疗的甲亢性心脏病患者68例作为观察组，同期选择在我院进行常规体检的健康者35例作为对照组。采用免疫放射法检测血清BNP水平，免疫比浊法检测血清CRP水平。比较两组血清BNP、CRP水平的差异及不同心功能甲亢性心脏病患者血清BNP、CRP水平，分析血清BNP、CRP水平与甲亢性心脏病患者心功能的相关性。结果：观察组血清BNP、CRP水平明显高于对照组，差异具有统计学意义(P<0.05)；观察组心功能Ⅱ级患者血清BNP、CRP水平明显高于心功能Ⅰ级患者(P<0.05)；心功能Ⅲ级患者血清BNP、CRP水平明显高于心功能Ⅱ级患者(P<0.05)；心功能Ⅳ级患者血清BNP、CRP水平明显高于心功能Ⅲ级患者(P<0.05)；观察组治疗后血清BNP、CRP水平较治疗前显著降低，差异具有统计学意义(P<0.05)。甲状性功能亢进性心脏病患者血清BNP、CRP水平均与其心功能等级呈显著正相关(r=0.742，P=0.037；r=0.857，P=0.011)。结论：甲亢性心脏病患者血清BNP与CRP水平均显著升高，可能用于甲亢并发甲亢性心脏病的早期诊断及心功能评估的重要参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study the serum BNP and CRP Levels in the Patients with hyperthyroid heart disease and their correla- tion with the cardiac function. Methods: 58 patients of hyperthyroid heart disease who were treated from October 2015 to March 2017 in our hospital were selected as the observation group, 35 cases of healthy subjects in the hospital for regular physical examination were se- lected as the control group. The serum CRP and BNP levels were detected by immunoradiometricassay and immunoturbidimetry respec- tively and compared among patients with different heart function, the correlation of serum CRP and BNP levels with heart function of hy- perthyroidism heart disease patient were analyzed. Results: The serum BNP, CRP levels of observation group were higher than those of the control group(P<0.05). The serym BNP, CRP levels of patients with center function Ⅱ in the observation group was higher than that of the patients with cardiac function grade Ⅰ(P<0.05); the serum BNP, CRP levels of patients with center function Ⅲ in the observation group were higher than those of the patients with cardiac function grade Ⅱ(P<0.05); the serum BNP, CRP levels of patients with center function Ⅳ in Observation group were higher than those of the patients with cardiac function grade Ⅲ(P<0.05), After treatment, the serum BNP, CRP level of observation group were lower than those before treatment(P<0.05). The serum BNP and CRP levels of patients with hyperthyroid heart disease were positively correlated with the cardiac function (r=0.742, P=0.037; r=0.857, P=0.011). Conclusion: The serum BNP and CRP levels were significantly elevated in the patients with hyperthyroid heart disease, detecting the serum BNP and CRP levels can contribute to the early diagnosis of hyperthyroidism complicated with hyperthyroidism heart disease and effectively eval- uate the cardiac function classification. |
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