| 孙晓娟,冯武龙,侯 娜,李 娜,姜蔚丽.有氧运动对2型糖尿病大鼠肾组织STAT3及VEGF表达的影响[J].现代生物医学进展英文版,2018,(18):3440-3444. |
| 有氧运动对2型糖尿病大鼠肾组织STAT3及VEGF表达的影响 |
| Effects of Aerobic Exercise on the Expression of STAT3 and VEGF in Kidney Tissue of Type 2 Diabetes Rats |
| Received:May 06, 2018 Revised:June 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.18.008 |
| 中文关键词: 2型糖尿病 有氧运动 肾脏损伤 STAT3 VEGF |
| 英文关键词: Type 2 diabetes Aerobic exercise Renal injury STAT3 VEGF |
| 基金项目:陕西省教育厅科学研究计划项目（16JK1830）；2016国家级大学生创新创业训练计划资助项目（201610722029） |
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| 中文摘要: |
| 摘要 目的：研究有氧运动对2型糖尿病大鼠肾组织转录激活因子3（activators of transcription 3, STAT3）及血管内皮生长因子（vascular endothelial growth factor, VEGF）表达的影响及其机制。方法：健康雄性SD大鼠55只，采用高糖高脂饲料喂养加腹腔注射低剂量链脲佐菌素（STZ）制作２型糖尿病大鼠模型。实验分为正常对照组，糖尿病安静组和糖尿病运动组。糖尿病运动组大鼠进行8周的有氧运动，其它两组不进行干预。检测血糖、24 h UA、BUN、Scr的变化；检测肾组织VEGF、STAT3和STAT3 mRNA的表达。结果：与正常对照组相比，糖尿病安静组大鼠血糖、24 h UA、BUN和Scr均显著升高（P<0.05）；糖尿病运动组大鼠血糖、24 h UA、BUN和Scr均较糖尿病安静组显著下降（P<0.05）。糖尿病安静组大鼠肾组织VEGF、STAT3和STAT3 mRNA的表达量分别为(0.417±0.121)、(0.527±0.139)和(2.86±0.32)，均较正常对照组明显增加（P<0.05）；糖尿病运动组大鼠肾组织VEGF、STAT3和STAT3 mRNA的表达量分别为(0.225±0.076)、(0.298±0.082)和(1.74±0.25)，均较糖尿病安静组明显减少（P<0.05）。结论：有氧运动对糖尿病所致肾损伤有一定改善作用，其保护机制可能与下调肾组织STAT3 mRNA的表达，使STAT3和VEGF合成减少有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of aerobic exercise on STAT3 and VEGF in kidney tissue of type 2 diabetes rats and its mechanism. Methods: The model of type 2 diabetic rats was established through 55 SD rats fed high-fat diet together with in- traperitoneal infecting after a low dose of STZ. The rats were randomly divided into normal control group, diabetic control group and dia- betic exercise group. The diabetic exercise group was intervened of exercise for 8 weeks. We examined blood glucose concentrations, 24 h UA, BUN, Scr, and the expressions of VEGF, STAT3 and STAT3 mRNA in kidney tissue. Results: Compared with normal control group, the blood glucose concentrations, 24 h UA, BUN and Scr increased significantly in diabetic control group(P<0.05). The blood glu- cose concentrations, 24 h UA, BUN and Scr decreased significantly in diabetic exercise group than in diabetic control group (P<0.05). The expressions of VEGF, STAT3 and STAT3 mRNA in diabetic control group were (0.417±0.121), (0.527±0.139) and (2.86±0.32) respectively, and they were significantly higher than normal control group (P<0.05); The expressions of VEGF, STAT3 and STAT3 mRNA in diabetic exercise group were (0.225±0.076), (0.298±0.082) and (1.74±0.25) respectively, and they were significantly lower than di- abetic control group (P<0.05). Conclusion: Aerobic exercise could protect renal injury in type 2 diabetes rats, which may be related to downregulate the expression of STAT3 mRNA, and decrease the synthesis of STAT3 and VEGF. |
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