| 王赐玉,黄昭瑄,黄昭穗,栾丽丽,何艺芬.糖尿病患者足部溃疡感染的病原菌分布及药敏性分析[J].现代生物医学进展英文版,2018,(17):3327-3331. |
| 糖尿病患者足部溃疡感染的病原菌分布及药敏性分析 |
| Distribution of Pathogens and Analysis of Drug Susceptibility on Patients with Diabetic Foot Ulcer Infection |
| Received:November 05, 2017 Revised:November 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.17.027 |
| 中文关键词: 糖尿病 足部溃疡 病原菌分布 药敏性 感染 |
| 英文关键词: Diabetes Foot ulcer Distribution of pathogens Drug susceptibility Infected |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：研究糖尿病患者足部溃疡感染的病原菌分布及药敏性。方法：选取2016年2月至2017年2月我院收治的糖尿病足患者102例作为研究对象，采用全自动细菌鉴定仪和Kirby-Baure（K-B）法分别检测所有患者足部溃疡分泌物中病原菌分布和药敏性。结果：96例成功分离出菌株的糖尿病患者足部溃疡分泌物中共分离出107株菌株，其中革兰阴性菌61株（57.01%）、革兰阳性菌43株（40.19%）和真菌3株（2.80%），占总菌株百分比前三位的病原菌分别为金黄色葡萄球菌22株（20.56%）、奇异变形杆菌14株（13.08%）和肺炎克雷伯菌10株（9.35 %）；前三位革兰阴性菌（奇异变形杆菌、肺炎克雷伯菌和大肠埃希菌）对亚胺培南、美罗培南、头孢哌酮及阿米卡星的敏感性较高（高于90.00%）；金黄色葡萄球菌和表皮葡萄球菌对万古霉素、利奈唑胺及利福平敏感性较高（高于95.00%）；粪肠球菌对红霉素、氨苄西林、万古霉素及利奈唑胺敏感性较高（高于90.00%）。结论：糖尿病患者足部溃疡感染的病原菌以金黄色葡萄球菌和奇异变形杆菌为主，耐药情况严峻，临床诊疗过程中应根据药敏结果规范使用抗菌药物。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the distribution of pathogens and analysis of drug susceptibility on diabetic foot ulcer infec- tion. Methods: 102 patients with diabetic foot who were treated in our hospital from February 2016 to February 2017 were selected as the subjects, fully automatic bacteria identification and Kirby-Baure(K-B) was used to detect the distribution of pathogens and analysis of drug susceptibility of all patients with diabetic foot ulcer infection respectively. Results: Separated 107 strains bacteria from the secretions of 96 patients with diabetic foot ulcer infection, including 61 strain (57.01%) of gram-negative bacteria, 43 strains (40.19%) of gram posi- tive bacteria and 3 strains of fungi strains (2.80%). Among the percentage of total isolates, the three pathogens were staphylococcus au- reus 22 strains (20.56%), proteus mirabilis 14 strains (13.08%) and klebsiella pneumoniae 10 strains (9.35%). The top three gram-nega- tive bacteria (proteus mirabilis, klebsiella pneumonia and escherichia coli) were highly sensitive to imipenem, meropenem, cefoperazone and amikacin (higher than 90.00%), staphylococcus aureus and staphylococcus epidermidis were highly sensitive to vancomycin, linezolid and rifampin (higher than 95.00%), enterococcus faecalis was highly sensitive to erythromycin, ampicillin, vancomycin and linezolid (higher than 90.00%). Conclusion: The main pathogens of diabetic foot ulcer infection are staphylococcus aureus and singular proteus, the drug resistance is severe, and antimicrobial agents should be used according to the results of drug sensitivity in clinical diagnosis and treatment. |
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