| 徐 慧,陈凤干,王 静,薛迎峰,逄曙光.妊娠期糖尿病孕妇胎盘中HIF-1α、ET-1及VEGF的表达及与妊娠结局的关系研究[J].现代生物医学进展英文版,2018,(17):3323-3326. |
| 妊娠期糖尿病孕妇胎盘中HIF-1α、ET-1及VEGF的表达及与妊娠结局的关系研究 |
| The Relationship Research between the Expression of HIF-1α, ET-1, VEGF in Placenta of Pregnant Women with Gestational Diabetes and the Pregnancy Outcome |
| Received:April 04, 2018 Revised:April 28, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.17.026 |
| 中文关键词: 妊娠期糖尿病 缺氧诱导因子-1α 内皮素-1 血管内皮生长因子 妊娠结局 相关性 |
| 英文关键词: Gestational diabetes Hypoxia inducible factor-1α Endothelin-1 Vascular endothelial growth factor Pregnancy out- come Correlation |
| 基金项目:山东省自然科学基金项目（ZR2014YL493） |
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| 中文摘要: |
| 摘要 目的：探讨妊娠期糖尿病孕妇胎盘中缺氧诱导因子-1α（HIF-1α）、内皮素-1（ET-1）及血管内皮生长因子（VEGF）的表达及与妊娠结局的关系。方法：选取2015年8月至2016年10月间济南市中心医院收治的妊娠期糖尿病患者80例。根据患者血糖控制效果分为血糖控制不良组（A组）40例和血糖控制良好组（B组）40例，另取同期于我院体检的健康孕妇40例为C组。应用免疫组化SP法检测各组胎盘中HIF-1α、ET-1及VEGF的表达情况，观察各组不良妊娠结局发生情况，并分析妊娠期糖尿病孕妇胎盘中HIF-1α、ET-1及VEGF的表达与妊娠结局相关性。结果：A组孕妇胎盘中HIF-1α、ET-1及VEGF的阳性表达率均高于B组与C组，B组HIF-1α、VEGF的阳性表达率高于C组（P<0.05）。A组羊水过多、巨大儿、产后出血的发生率均高于B组与C组，胎儿窘迫、妊娠高血压的发生率高于C组，B组胎儿窘迫、羊水过多、产后出血、妊娠高血压的发生率高于C组（P<0.05）。经Spearman相关性分析可得，妊娠期糖尿病孕妇胎盘中HIF-1α、ET-1及VEGF的表达与妊娠高血压、产后出血、巨大儿、羊水过多、胎儿窘迫等不良妊娠结局呈正相关（P<0.05）。结论：妊娠期糖尿病孕妇胎盘中HIF-1α、ET-1及VEGF呈高表达，其表达会增加不良妊娠结局的发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of hypoxia inducible factor-1α(HIF-1α), endothe- lin-1(ET-1), vascular endothelial growth factor (VEGF) in placenta of pregnant women with gestational diabetes and the pregnancy out- come. Methods: 80 cases of gestational diabetes treated in Ji'nan Central Hospital from August 2015 to October 2016 were selected. Ac- cording to the effect of blood glucose control, the patients were divided into poor control of blood glucose of 40 cases (group A) and good control of blood glucose of 40 cases (group B), 40 cases of healthy pregnant women in the same period in our hospital were selected as group C. The expression of HIF-1α, ET-1, VEGF in placenta of each group were detected by immunohistochemical SP method. The incidence of adverse pregnancy outcomes in each group were observed. The correlation between the expression of HIF-1α, ET-1, VEGF in placenta of pregnant women with gestational diabetes and the pregnancy outcome were analyzed. Results: The positive expression rate of HIF-1α, ET-1, VEGF in group A were higher than that in group B and group C, the positive expression rate of HIF-1α, VEGF in group B were higher than that in group C (P<0.05). The incidence of hydramnios, macrosomia and postpartum hemorrhage in group A were higher than that in group B and group C, the incidence of fetal distress and hypertension of pregnancy were higher than that in group C, and the incidence of fetal distress, hydramnios, postpartum hemorrhage and hypertension of pregnancy in group B were higher than that in group C (P<0.05). Spearman correlation analysis showed that the expressions of HIF-1α, ET-1, VEGF in placenta of pregnant women with gestational diabetes were positively correlated with adverse pregnancy outcomes such as hypertension of pregnancy, post- partum hemorrhage, macrosomia, hydramnios and fetal distress (P<0.05). Conclusion: The high expression of HIF-1α, ET-1, VEGF in placenta of pregnant women with gestational diabetes can increase the incidence of bad pregnancy outcomes. |
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