| 范 涛,胡振飞,戴晓雯,胡 云,洪 毅.包虫病患者血清中可溶性Tim3/Galectin9水平的表达及临床意义[J].现代生物医学进展英文版,2018,(17):3297-3300. |
| 包虫病患者血清中可溶性Tim3/Galectin9水平的表达及临床意义 |
| Expression of Soluble Tim3/Galectin9 in Serum of Patients with Hydatidosis and its Clinical Significance |
| Received:November 25, 2017 Revised:December 21, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.17.020 |
| 中文关键词: 包虫病 Tim3 Galectin9 Th1/Th2细胞 相关性 |
| 英文关键词: Hydatidosis Tim3 Galectin9 Th1/Th2 cell Correlation |
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| 中文摘要: |
| 摘要 目的：研究包虫病患者血清中可溶性T细胞免疫球蛋白及黏蛋白分子3（Tim3）/半乳糖凝集素9（Galectin9）水平的表达及临床意义。方法：选取2015年2月至2016年12月于我院接受治疗的包虫病患者40例作为包虫病组，另选取同期于我院接受体检的健康志愿者40例作为健康对照组，采用酶联免疫吸附法检测两组人员的血清Tim3、Galectin9、γ-干扰素（IFN-γ）、肿瘤坏死因子-α（TNF-α）、白细胞介素-4（IL-4）、白细胞介素-6（IL-6）水平，并分析包虫病患者血清Tim3、Galectin9水平与IFN-γ、TNF-α、IL-4、IL-6之间的相关性。结果：包虫病组患者血清Tim3、Galectin9水平均明显高于健康对照组（P＜0.05）。包虫病组患者血清IFN-γ、TNF-α较健康对照组明显更低，而IL-4、IL-6水平较健康对照组明显更高（P＜0.05）。经Pearson相关性分析可得：包虫病患者血清Tim3、Galectin9水平与血清IFN-γ、TNF-α均呈负相关关系，而与IL-4、IL-6水平均呈正相关关系（P＜0.05）。结论：包虫病患者血清可溶性Tim3/Galectin9水平异常升高，其主要作用机制可能与影响细胞因子IFN-γ、TNF-α、IL-4、IL-6水平变化有关，在包虫病的发生、发展过程中起着重要的作用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of soluble T cell immunoglobulin and mucin molecule 3 (Tim3) / galactose lectin 9 (Galectin9) in patients with hydatidosis. Methods: 40 patients with hydatid disease who were treated in our hospital from February 2015 to December 2016 were selected as hydatidosis group, another 40 healthy volunteers who underwent physi- cal examination in our hospital were selected as healthy control group in the same period, the serum levels of Tim3, Galectin9, interfer- on-γ (IFN-γ), tumor necrosis factor α (TNF-α), interleukin -4 (IL-4) and interleukin -6 (IL-6) levels were detected by enzyme linked im- munosorbent assay (ELISA) in the two groups, and the relationship between Tim3, Galectin9 and IFN-γ, TNF-α, IL-4 and IL-6 level were analyzed. Results: The levels of serum Tim3 and Galectin9 in hydatidosis group were significantly higher than those in healthy con- trol group (P<0.05). The levels of serum IFN-γ and TNF-α in hydatidosis group were lower than those in healthy control group, but the levels of IL-4 and IL-6 were significantly higher than those in healthy control group (P<0.05). Pearson correlation analysis showed that the serum levels of Tim3 and Galectin9 were negatively correlated with serum IFN-γ and TNF-α, but positively correlated with the levels of IL-4 and IL-6 (P<0.05). Conclusion: Serum soluble Tim3/Galectin9 levels are abnormally elevated in patients with hydatidosis, the main mechanism may be related to the changes of cytokines IFN-γ, TNF-α, IL-4 and IL-6 levels, which play important role in the occurrence and development of echinococcosis. |
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