| 刘振峰,梁治权,艾力江·阿斯拉,方 锐,邓迎杰,孟庆才.IL-1β基因多态性与新疆维吾尔族原发性膝骨关节炎发病的关系研究[J].现代生物医学进展英文版,2018,(17):3284-3288. |
| IL-1β基因多态性与新疆维吾尔族原发性膝骨关节炎发病的关系研究 |
| Relationship Research of IL-1β Gene Polymorphism and Primary Knee Osteoarthritis of Uygur Nationality in Xinjiang |
| Received:November 06, 2017 Revised:November 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.17.017 |
| 中文关键词: IL-1β 基因多态性 新疆维吾尔族 原发性膝骨关节炎 发病 关系 |
| 英文关键词: IL-1β Gene polymorphism Uygur nationality in Xinjiang Primary knee osteoarthritis Incidence Relationship |
| 基金项目:国家自然科学基金项目（81360549） |
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| 中文摘要: |
| 摘要 目的：研究白细胞介素-1β（IL-1β）基因多态性与新疆维吾尔族原发性膝骨关节炎（PKOA）发病的关系。方法：选择从2015年9月到2017年8月在我院就诊的新疆维吾尔族PKOA患者50例作为研究对象，记为观察组。另选同期在我院体检的新疆维吾尔族正常健康志愿者30例记为对照组，检测并对比两组血清IL-1β水平、IL-1β基因型频率的分布以及单体型的相关频率分布。结果：观察组的血清IL-1β水平明显高于对照组，差异有统计学意义（P＜0.05）；且观察组患者中，以IL-1β+3954CT的血清IL-1β水平最高，为（173.28±65.19）pg/mL，其次为IL-1β-511CT，水平为（172.17±54.98）pg/mL，二者均高于对照组，差异均有统计学意义（均P＜0.05）。观察组IL-1β-511C/T的CT、IL-1β+3954C/T的CT、等位基因T的基因型频率均分别明显高于对照组，IL-1β+3954C/T的CC、等位基因C的基因型频率均分别明显低于对照组，差异均有统计学意义（均P＜0.05）。根据SNPstats法分析单体型后发现，IL-1β共有6类单体型，其中以TCC最为常见，但TCT及CCC型同PKOA的发病率具有明显相关性（OR=3.214、6.074，均P＜0.05）。结论：IL-1β的基因多态性与新疆维吾尔族PKOA有关，临床主要表现为IL-1β-511C/T和IL-1β+3954C/T的CT基因型，且TCT及CCC单体型同PKOA的发病率联系紧密，通过监测IL-1β基因型，有助于更好地指导PKOA患者的治疗。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship research of Interleukin -1β(IL-1β) gene polymorphism and primary knee osteoarthritis (PKOA) of Uygur nationality in Xinjiang. Methods: 50 PKOA patients of Uygur nationality in Xinjiang who were treated in our hospital from September 2015 to August 2017 were selected as the research objects, and they were recorded as the observation group. 30 healthy volunteers of Uygur nationality in Xinjiang were selected as the control group, and the serum IL-1β levels, the distribution of IL-1β genotype frequencies and the frequency distribution of haplotypeswere were detected and compared between the two groups. Results: The level of serum IL-1β in the observation group was significantly higher than that in the control group, the difference was statistically significant (P<0.05). In the observation group, the serum IL-1β level with IL-1β+3954CT was the highest, which was (173.28±65.19) pg/mL, the second was IL-1β-511CT, which was (172.17±54.98) pg/mL, the two of them were higher than those of the control group, the differences were statistically significant(P<0.05). The CT of IL-1β-511C/T, IL-1β+3954C/T and the genotype frequency of allele T in the observation group were significantly higher than those in the control group, the CC of IL-1β+3954C/T and genotype frequency of allele C were significantly lower than those in the control group, the differences were statistically significant (P<0.05). According to SNPstats analysis, there were 6 haplotypes in IL-1β, TCC was the most common. However, the incidence of TCT and CCC was significantly correlated with the incidence of PKOA (OR=3.214, 6.074, all P<0.05). Conclusion: The genetic polymorphism of IL-1β is associated with PKOA of Uygur nationality in Xinjiang. The main clinical manifestation is CT genotype of IL-1β-511C/T and IL-1β 3954C/T, TCT and CCC haplotypes are closely associated with the incidence of PKOA, monitoring the genotypes of IL-1β may help to better guide the treatment of PKOA patients. |
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