| 唐 洁,宓轶群,孙旭妍,沈 瑾,董 风,陆建平.2型糖尿病患者尿微量白蛋白水平与动脉粥样硬化的相关性研究[J].现代生物医学进展英文版,2018,(17):3260-3263. |
| 2型糖尿病患者尿微量白蛋白水平与动脉粥样硬化的相关性研究 |
| Correlation Between Microalbuminuria and Atherosclerosis in Patients with Type 2 Diabetes Mellitus |
| Received:November 23, 2017 Revised:December 18, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.17.012 |
| 中文关键词: 2型糖尿病 尿微量白蛋白 动脉粥样硬化 相关性 生化指标 |
| 英文关键词: Type 2 diabetes mellitus Microalbuminuria Atherosclerosis Correlation Biochemical indexes |
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| 中文摘要: |
| 摘要 目的：研究2型糖尿病患者尿微量白蛋白（MAU）水平与动脉粥样硬化的相关性。方法：抽样选取2015年2月至2017年2月我体检中心检测的2型糖尿病患者500例，根据临床数据中MAU水平的不同分为异常组188例和正常组312例。分别对比两组患者的临床资料以及生化指标水平，并采用多因素Logistic回归分析法分析患者MAU异常的危险因素。结果：异常组患者的病程、BMI、空腹血糖、甘油三酯、腰臀比均高于正常组，而高密度脂蛋白水平低于正常组（P<0.05）。多因素Logistic回归分析显示影响2型糖尿病患者MAU异常的危险因素包括病程（较长）、BMI（较大）、收缩压（较高）、糖化血红蛋白（较高）、高密度脂蛋白（较低）（P<0.05）。结论：2型糖尿病患者的病程、BMI、收缩压、糖化血红蛋白、高密度脂蛋白均与MAU的发生密切相关，临床上可通过检查以上指标预测评估患者的病情变化以及预后情况。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between microalbuminuria (MAU) and atherosclerosis in patients with type 2 diabetes mellitus. Methods: A total of 500 patients with type 2 diabetes mellitus, who were examined in the Sixth People's Hospital Affili- ated to Shanghai Jiao Tong University during February 2015 to February 2017, were selected and were divided into abnormal group (n=188) and normal group (n=312) according to the different levels of MAU in clinical data.The clinical data and biochemical indexes of the two groups were compared, and the risk factors of MAU abnormalities were analyzed by multivariate Logistic regression analysis. Results: The course of disease, BMI, duration, fasting blood glucose, triglyceride and waist-to-hipratio in the abnormal group were higher than those in the normal group, while the levels of high density lipoprotein was lower than that in the normal group (P<0.05). Logistic re- gression analysis showed that the risk factors of MAU abnormalities in the patients with type 2 diabetes mellitus were the longer course of disease, larger BMI, higher systolic pressure, higher glycosylated hemoglobin, lower high density lipoprotein (P<0.05). Conclusion: The course of disease, BMI, systolic pressure, glycosylated hemoglobin and high density lipoprotein in the patients with type 2 diabetes mellitus are closely correlated with the occurrence of MAU. In the clinical work, the condition and prognosis of patients with type 2 dia- betes mellitus can be predicted by examining the above indexes. |
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