| 张惠桃,肖鸿文,李晓明.骨髓增生异常综合征中相关微小RNA的研究进展[J].现代生物医学进展英文版,2018,(15):2987-2991. |
| 骨髓增生异常综合征中相关微小RNA的研究进展 |
| Progress in Research of Related MicroRNAs in Myelodysplastic Syndromes |
| Received:December 30, 2017 Revised:January 26, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.15.042 |
| 中文关键词: 骨髓增生异常综合征 5q-综合征 急性髓系白血病 微小RNA |
| 英文关键词: Myelodysplastic Syndromes 5q-syndrome Acute myeloid leukemia MicroRNA |
| 基金项目: |
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| 中文摘要: |
| 摘要：骨髓增生异常综合征（MDS）是一组异质性后天性克隆性恶性疾病，其基本临床特征是骨髓中造血细胞有发育异常的形态学表现和外周血中三系血细胞减少，以及转变为急性髓细胞性白血病（AML）的危险性很高。其鉴别诊断、评估预后对治疗决策有重要意义。近年来认为表观遗传途径参与了MDS病因和发病机制。尤其微小RNA（miRNA）在MDS的发生、发展及疾病转归中起了重要作用。本文通过miRNA的临床可监测性、与血液疾病的联系这两个方面阐述了相关miRNA研究的意义和地位；重点对MDS的诊断和临床进展中可能发挥重要作用的miRNA以及5q-综合征中miR145和miR146a等表达具有特殊性的miRNA进行了综述。以期能够在此基础上进行更深入的研究探索，使miRNA在骨髓异常增生综合征的临床诊疗中发挥更大的潜力。 |
| 英文摘要: |
| ABSTRACT: Myelodysplastic syndrome is a heterogeneous group of acquired malignant diseases of the clones. Its basic clinical features are that the hematopoietic cells in the bone marrow have abnormal morphological manifestations and the reduction of the three-line blood cells in the peripheral blood, and high risk of conversion to acute myeloid leukemia. The differential diagnosis of MDS, to assess the prognosis of treatment decisions are of great significance. In recent years, epigenetic pathway participates in the etiology and pathogenesis of MDS, especially microRNA plays an important role in the occurrence, development and prognosis of MDS. This article expounds the significance and status of related miRNA research through the relationship between the clinical monitorability of miRNA and blood diseases; and focus on the miRNAs that may play an important role in the diagnosis and clinical progress of MDS, as well as the expression of miRNAs that are specific to miR145 and miR146a in 5q-syndrome. With a view to be able to carry out more in-depth research and exploration on this basis, miRNA in the clinical diagnosis and treatment of myelodysplastic syndrome play more potential. |
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