| 范群雄,张焕鑫,李 波,沈 俊,赵继先.不同剂量阿托伐他汀对老年急性冠脉综合征患者经PCI术后血清炎症因子水平和内皮功能的影响[J].现代生物医学进展英文版,2018,(15):2937-2941. |
| 不同剂量阿托伐他汀对老年急性冠脉综合征患者经PCI术后血清炎症因子水平和内皮功能的影响 |
| Effects of Different Doses of Atorvastatin on the Blood Lipid, Serum Inflammatory Factors Levels and Vascular Endothelial Function of Elderly Patients with Acute Coronary Syndrome after PCI |
| Received:November 09, 2017 Revised:December 12, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.15.030 |
| 中文关键词: 阿托伐他汀 急性冠脉综合征 血脂 炎症因子 血管内皮功能 |
| 英文关键词: Atorvastatin Acute coronary syndrome Blood lipid Inflammatory factors Vascular endothelial function |
| 基金项目:湖北省卫生厅计划项目(鄂卫2015-53) |
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| 中文摘要: |
| 摘要 目的：探讨不同剂量阿托伐他汀对老年急性冠脉综合征患者经PCI(经皮冠状动脉介入治疗，percutaneous coronary interven- tion)术后血脂、血清炎症因子水平及血管内皮功能的影响。方法：选取2015年8月至2017年4月我院收治的老年急性冠脉综合征患者80例，依据随机数据表法分为观察组和对照组，每组40例。对照组给予小剂量阿托伐他汀(20 mg/d)治疗，观察组给予大剂量阿托伐他汀(40 mg/d)治疗。比较两组治疗前后总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)、低密度脂蛋白胆固醇(low-density lipoprotein, LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein, HDL-C)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、白介素-6(interleukin-6, IL-6)、肿瘤坏死因子(tumor necrosis factor-α，TNF-α)、一氧化氮(nitric oxide, NO)及内皮素-1(endothelin-1, ET-1)水平的变化。结果：治疗前，两组血清TC、TG、LDL-C、HDL-C、hs-CRP、IL-6、TNF-α、NO及ET-1水平比较差异均无统计学意义(P＞0.05)；治疗后，两组血清TC、TG、LDL-C、hs-CRP、IL-6、TNF-α及ET-1水平与本组治疗前相比均显著性降低，且观察组治疗后血清TC、TG、LDL-C、hs-CRP、IL-6、TNF-α及ET-1的水平均显著低于对照组(P<0.05)；两组血清HDL-C、NO水平与治疗前相比均显著性升高(P<0.05)，且观察组治疗后的血清HDL-C、NO水平显著高于对照组(P<0.05)。结论：阿托伐他汀用于经PCI术治疗的老年ACS患者可显著减轻再灌注后的炎症反应，降低血脂水平并改善内皮功能，且大剂量阿托伐他汀的治疗效果明显优于小剂量治疗。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different dosages of atorvastatin on the blood lipid, inflammatory factors and vascular endothelial function of patients with acute coronary syndrome (ACS). Methods: According to random data table method, a total of 80 patients with ACS from August 2015 to April 2017 were divided into the observation group and the control group, with 40 cases in each group. The control group was treated with small dose atorvastatin (20 mg/d); the observation group was given large dose atorvastatin (40 mg/d). The levels of serum TC, TG, LDL-C, HDL-C, hs-CRP, IL-6, TNF-α, NO and ET-1 in two groups before and after treatment were compared. Results: The levels of serum TC, TG, LDL-C, HDL-C, hs-CRP, IL-6, TNF-α, NO and ET-1in both groups before treat- ment showed no statistically significant difference(P>0.05). After treatment, the levels of serum TC, TG, LDL-C, hs-CRP, IL-6, TNF-α and ET-1 in both groups were significantly lower than those in the same group before treatment (P<0.05), and which were significantly lower in the observation group than those of the control group; the levels of serum HDL-C, NO in both groups after treatment were signif- icantly higher than those in the same group before treatment(P<0.05), which were significantly higher in the observation group than those of the control group(P<0.05). Conclusion: For elderly patients with ACS undergoing PCI surgery, atorvastatin can better reduce the in- flammatory response factors, lower the level of blood lipids and improve endothelial function, and the effect of high-dose treatment was significantly better than low-dose treatment. |
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