| 林斯妤,陈若文,杨 妺,熊晓兰,张世忠.中枢神经系统神经胶质细胞对神经病理性疼痛的调节作用[J].现代生物医学进展英文版,2018,(14):2788-2791. |
| 中枢神经系统神经胶质细胞对神经病理性疼痛的调节作用 |
| Moderating Effect of Neuroglial Cells in the Central Nervous System on Neuropathic Pain |
| Received:January 04, 2018 Revised:January 26, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.14.042 |
| 中文关键词: 神经病理性疼痛 小胶质细胞 星形胶质细胞 少突胶质细胞 |
| 英文关键词: Neuropathic pain Microglia Astrocytes Oligodendrocytes |
| 基金项目:湖北省自然科学基金项目（2010CDZ068） |
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| 中文摘要: |
| 摘要：神经病理性疼痛是一种临床的常见疾病，严重影响了患者及家属的生活质量，给社会带来了沉重的负担。神经病理性疼痛的发病机制及有效治疗仍在探索中。中枢神经系统内有三种胶质细胞，包括小胶质细胞、星形胶质细胞以及少突胶质细胞。近来有研究发现，这三种胶质细胞可通过活化、产生和释放细胞因子等途径参与神经病理性疼痛的调节。探索神经胶质细胞的多种复杂功能或作用机制来充分认识胶质细胞的特点，为今后神经病理性疼痛的临床治疗提供新的思路。本文通过研究小胶质细胞、星形胶质细胞以及少突胶质细胞的特点及其对神经病理性疼痛的影响，并分析中枢神经系统胶质细胞与疼痛治疗之间的相关性，旨在总结神经病理性疼痛的发生和发展过程中小胶质细胞、星状胶质细胞及少突胶质细胞的调节作用。 |
| 英文摘要: |
| ABSTRACT: Neuropathic pain is a common clinical disease, which seriously affects the life quality of the patients and their fami- lies, and brings a heavy burden to the society. The pathogenesis and effective treatment of neuropathic pain are still being explored. There are three kinds of neuroglial cells in the central nervous system, including microglia, astrocytes and oligodendrocytes. Recent studies have found that, these three neuroglial cells can be involved in the moderating of neuropathic pain by activating, producing and releasing cytokines. Explore the complex functions or mechanisms of neuroglial cells to fully understand the characteristics of neuroglial cells, and provide new ideas for the clinical treatment of neuropathic pain in the future. This article the characteristics of microglia, astrocytes and oligodendrocytes, and their effects on neuropathic pain were studied, and the correlation between neuroglial cells and pain treatment in the central nervous system was analyzed, the aim to summarize the moderating effect of microglia, astrocytes and oligodendrocytes in the occurrence and development of neuropathic pain. |
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