| 周冬梅,张 瑞,滑 玮,宋 晖,陈必良.miRNA-139-5p与肿瘤[J].现代生物医学进展英文版,2018,(14):2780-2783. |
| miRNA-139-5p与肿瘤 |
| miRNA-139-5p and Tumor |
| Received:January 17, 2018 Revised:February 12, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.14.040 |
| 中文关键词: miR-139-5p 肿瘤 肿瘤恶性行为 |
| 英文关键词: MiR-139-5p Tumor Malignant process |
| 基金项目:国家自然科学基金项目（81602265） |
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| 中文摘要: |
| 摘要：转移和复发是恶性肿瘤的重要特征。肿瘤细胞的增殖、浸润、侵袭能力与肿瘤的复发和转移息息相关。非编码小RNA通过转录后水平参与肿瘤的发生和发展过程。其中，miR-139-5p成为研究热点之一。在许多肿瘤中都发现miR-139-5p的异常表达，它参与了肿瘤细胞的增殖、分化、转移和浸润，调节肿瘤细胞对化疗药物敏感性，并与肿瘤患者的预后相关。因此，miR-139-5p可能成为肿瘤治疗的一个新靶点。本文对miR-139-5p与肿瘤的关系作一综述。系统地了解它在恶性肿瘤进程中的作用，为广大研究者及临床工作者提供新思路新方法。 |
| 英文摘要: |
| ABSTRACT: Malignant tumor is characterized by recurrence and metastasis, Which is relevant to cellular proliferation and ability of invasion. Several studies have demonstrated that microRNAs(miRNAs) are associated with cancer progression and carcinogenesis at the post-transcription level. MiRNA-139-5p, which is one of the hot topics, was identified to be dysregulation in many cancers. It has been involved in various biological processes, including proliferation, cellular differentiation, invasion and metastasis, as well as chemo-resistance and prognosis of the tumor patients. Consequently, miRNA-139-5p may serve as a new potential therapeutic target for the treatment of tumor in the future. This paper reviewed the relationship between miRNA-139-5p and tumor. |
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