| 曹新建,王 嵘,王学军,李晓兴,吴继伟.神经外科重症监护病房耐万古霉素肠球菌感染的流行特征及危险因素研究[J].现代生物医学进展英文版,2018,(14):2755-2758. |
| 神经外科重症监护病房耐万古霉素肠球菌感染的流行特征及危险因素研究 |
| Epidemiological Characteristics and Risk Factors of Vancomycin Resistant Enterococcus Infection in Intensive Care Unit of Department of Neurosurgery |
| Received:August 31, 2017 Revised:September 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.14.034 |
| 中文关键词: 神经外科 重症监护病房 耐万古霉素肠球菌 感染 危险因素 |
| 英文关键词: Department of Neurosurgery Intensive care unit Vancomycin resistant enterococcus Infection Risk factors |
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| 中文摘要: |
| 摘要 目的：探讨神经外科重症监护病房（ICU）耐万古霉素肠球菌（VRE）感染的流行特征及危险因素，为临床防控提供参考依据。方法：选择2014年1月至2016年1月在我院接受手术治疗的神经外科ICU住院患者420例为研究对象。比较VRE感染患者在感染前抗生素的应用情况，并分别应用单因素及多因素Logistic回归分析分析VRE感染患者的危险因素，提出防控措施。结果：420例ICU住院患者中，VRE感染者58例，占13.81%。VRE感染患者在感染前应用的抗生素以三代头孢最多，占37.93%，以四代头孢最少，占6.90%。由单因素及多因素Logistic回归分析显示，ICU住院时间≥14 d、留置尿管≥14 d、格拉斯哥昏迷量表（GCS）评分＜8分以及附近存在VRE感染者均为VRE感染患者的危险因素（P<0.05）。结论：VRE感染患者在感染前应用的抗生素以三代头孢最多，ICU住院时间>14 d、留置尿管>14 d、GCS评分<8分以及附近存在VRE感染者均为VRE感染患者的危险因素，临床上应合理应用抗生素，采取相应的防控措施，降低VRE感染的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the epidemiological characteristics and risk factors of vancomycin resistant enterococcus (VRE) infection in intensive care unit (ICU) of department of neurosurgery, and to provide reference for clinical prevention and control. Methods: A total of 420 patients, who underwent surgery in the ICU of department of neurosurgery in Taizhou Hospital of Traditional Chinese Medicine from January 2014 to January 2016, were chosen as subjects. The application of antibiotics before infection in the pa- tients with VRE infection was compared, and univariate and multivariate Logistic regression analysis were used to analyze the risk factors of VRE infection to propose the prevention and control measures. Results: Among the 420 inpatients in ICU, there were 58 cases of VRE infection, accounted for 13.81%. The most common antibiotics used before VRE infection was three generation cephalosporin, accounted for 37.93%, and four generation cephalosporin was least, accounted for 6.90%. Single factor and Logistic regression analysis showed that the ICU hospitalization time≥14 d, indwelling catheter≥14 d, Glasgow Coma Scale (GCS) score<8 and patients infected by VRE near- by were the risk factors of VRE infection（P<0.05）. Conclusion: The most common antibiotics used before VRE infection is three genera- tion cephalosporin. ICU hospitalization time≥14 d, indwelling catheter≥14 d, GCS score<8 and patients infected by VRE nearby are the risk factors of VRE infection. Rational use of antibiotics and taking corresponding prevention and control measures are necessary in the clinical practice to reduce the incidence of VRE infection. |
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