| 孙 锎,罗 萍,韩鹏凯,余 龙,雷 丽.支原体肺炎患者治疗后血清SP-A、SP-D与hs-CRP的变化趋势及临床意义[J].现代生物医学进展英文版,2018,(14):2730-2733. |
| 支原体肺炎患者治疗后血清SP-A、SP-D与hs-CRP的变化趋势及临床意义 |
| Variation Tendency and Clinical Significance of Serum SP-A, SP-D and hs-CRP in Patients with Mycoplasma Pneumonia after Treatment |
| Received:September 13, 2017 Revised:October 08, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.14.028 |
| 中文关键词: 支原体肺炎 SP-A SP-D 超敏C反应蛋白 变化趋势 |
| 英文关键词: Mycoplasma pneumonia SP-A SP-D Hypersensitivity C reactive protein Variational tendency |
| 基金项目:重庆市卫计委医学科研计划基金资助项目(20142378) |
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| 中文摘要: |
| 摘要 目的：研究支原体肺炎（MP）患者血清肺表面活性蛋白-A（SP-A）、肺表面活性蛋白-D（SP-D）与超敏C反应蛋白（hs-CRP）的变化趋势及临床意义。方法：选择从2015年9月到2016年9月在我院治疗的MP患者56例纳入本次研究，将其记为观察组，给予常规治疗后，有效者49例，无效者7例。另选同期在我院进行健康体检的志愿者55例作为对照组，对比两组血清SP-A、SP-D及hs-CRP的变化趋势，比较观察组不同治疗结果患者的血清SP-A、SP-D及hs-CRP水平，并分析患者的血清SP-A、SP-D与hs-CRP的相关性。结果：治疗后3d及治疗后7d观察组的血清SP-A、SP-D及hs-CRP水平较治疗前依次降低，但均高于对照组（P＜0.05），在治疗后14d血清SP-A、SP-D及hs-CRP水平较治疗前降低（P＜0.05），但与对照组比较差异无统计学意义（P＞0.05）。治疗后14 d有效组血清SP-A、SP-D及hs-CRP水平均明显低于无效组，差异有统计学意义（P＜0.05）。根据Spearman相关性分析结果显示，MP患者的血清SP-A、SP-D与hs-CRP均呈正相关（r=0.713、0.699，P=0.000、0.000）。结论：MP患者的血清SP-A、SP-D及hs-CRP水平可伴随治疗过程的进行而逐渐回落，最终基本恢复至正常范围，且血清SP-A、SP-D水平与hs-CRP水平呈正相关，临床治疗时可针对上述3种指标进行监测以判断患者病情及治疗效果。 |
| 英文摘要: |
| ABSTRACT Objective: To study the variation tendency and clinical significance of serum pulmonary surfactant protein-A (SP-A), pulmonary surfactant protein-D (SP-D) and hypersensitive C reactive protein (hs-CRP) in patients with mycoplasma pneumonia (MP). Methods: A total of 56 patients with MP, who were treated in Central Hospital of Chongqing Three Gorges from September 2015 to September 2016, were chosen as obse 55 volunteers, who underwent physical examination in the hospital, were selected as control group.The variation tendency of serum SP-A, SP-D and hs-CRP was compared between the two groups. The levels of serum SP-A,SP-D and hs-CRP of different treatment results in the observation group were compared, and the correlation of serum SP-A, SP-D and hs-CRP was analyzed. rvation group. After routine treatment, 49 cases were effective, and 7 cases were invalid. At the same time. Results: Compared with before treatment, 3 d and 7 d after treatment, the levels of serum SP-A, SP-D and hs-CRP in the observation group were decreased gradually, which were significantly higher than those in the control group (P<0.05); 14 d after treatment, the levels of serum SP-A, SP-D, hs-CRP in the observation group were decreased,but there was not significant difference compared with the control group (P>0.05). 14 d after treatment, the levels of serum SP-D, SP-A and hs-CRP of the effective group were significantly lower than those of the invalid group, the difference was statistically significant (P<0.05). The results of Spearman correlation analysis showed that the serum levels of SP-A and SP-D of patients with MP were positively correlated with hs-CRP (r=0.713, 0.699, P=0.000, 0.000). Conclusion: The levels of serum SP-A, SP-D and hs-CRP in patients with MP are gradually declined with the course of treatment, and they recover to the normal range finally; the serum levels of SP-A and SP-D are positively correlated with the level of hs-CRP. The above three indicators can be monitored in clinical treatment so as to judge the patient's condition and the effect of treatment. |
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