| 李 辉,戚正涛,张 瑶,宋文集,陈凯达.活血化瘀中药复方治疗急性脑出血的疗效及对相关血清指标的影响[J].现代生物医学进展英文版,2018,(14):2688-2691. |
| 活血化瘀中药复方治疗急性脑出血的疗效及对相关血清指标的影响 |
| Effect of Chinese Herbal Medicine for Activating Blood Stasis on Acute Cerebral Hemorrhage and its Influence on Related Serum Indexes |
| Received:November 09, 2017 Revised:November 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.14.018 |
| 中文关键词: 活血化瘀中药复方 急性 脑出血 超敏C反应蛋白 白细胞介素-6 疗效 |
| 英文关键词: Chinese herbal medicine for activating blood stasis Acute Cerebral hemorrhage Hypersensitive C-reactive protein Interleukin-6 Efficacy |
| 基金项目:广东省中医药管理局立项资助课题（20171144） |
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| 中文摘要: |
| 摘要 目的：探讨活血化瘀中药复方治疗急性脑出血的疗效及对星形胶质源性蛋白（S100β）、N-末端脑钠素原（NT-proBNT）、血清超敏C反应蛋白（hs-CRP）及白细胞介素-6（IL-6）水平的影响。方法：选择2015年3月到2016年7月84例在我院接受治疗的急性脑出血患者，随机分为对照组（n=42）和试验组（n=42）。对照组患者给予抗血小板、降脂、营养神经、抗凝、自由基清除、降低颅内压、静脉滴注依达拉奉等常规治疗，试验组在此基础上给予活血化瘀中药复方，疗程均为14d。观察并比较两组患者临床疗效、不良反应及治疗前后脑血肿体积、欧洲脑卒中评分（ESS）。检测并比较两组患者治疗前后血清S100β、NT-proBNT、hs-CRP及IL-6水平。结果：两组患者不良反应发生率比较差异无统计学意义（P>0.05）。试验组总有效例数37例，对照组总有效例数28例，总有效率高于对照组，有统计学差异（P<0.05）。两组患者治疗后ESS评分高于治疗前，脑血肿体积小于治疗前，并且试验组患者ESS评分高于对照组，脑血肿体积小于对照组，差异具有统计学意义（P<0.05）。两组患者治疗后血清S100β、NT-proBNT、hs-CRP及IL-6水平低于治疗前，试验组上述指标为（1.02±0.21）ng/mL、（120.26±19.47）pmol/L、（8.33±1.45）mg/L、（11.25±2.71）pg/mL，低于对照组的（1.45±0.24）ng/mL、（219.68±22.51）pmol/L、（16.92±2.70）mg/L、（20.07±4.62）pg/mL，有统计学差异（P<0.05）。结论：对于急性脑出血患者，采用活血化瘀中药复方治疗其临床疗效确切，降低炎症反应，改善血清S100β、NT-proBNT水平，安全性较好，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of Chinese herbal medicine for activating blood stasis on acute cerebral hemorrhage and the influence of stellate source sex protein (S100β), N-terminal proBNP (NT-proBNT), serum hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6). Methods: 84 patients with acute cerebral hemorrhage treated in our hospital from March 2015 to July 2016 were selected. The patients were randomly divided into control group (n=42) and experimental group (n=42). The control group was given antiplatelet, lipid-lowering, nutritional nerve, anticoagulant, free radical scavenging, intracranial pressure reduction, intravenous drip of Edaravone and other conventional treatment. The experimental group were treated with Chinese herbal medicine for activating blood stasis on the basis of the control group. The two groups were treated for 14 days. The clinical efficacy, adverse reactions, cerebral hematoma volume, the European stroke score (ESS) before and after treatment were observed and compared between the two groups. The serum levels of S100β, NT-proBNT, hs-CRP, IL-6 between the two groups before and after treatment were compared. Results: There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The total effective cases were 37, and the control group were 28, the total effective rate was higher than that in the control group, the difference was statistically significant (P<0.05). The ESS scores of the two groups after treatment were higher than before treatment, the cerebral hematoma volume was less than before treatment, and the ESS scores of the experimental group were higher than that of the control group, the cerebral hematoma volume was less than that of the control group, the differences were statistically significant (P<0.05). After treatment, serum S100, NT-proBNT, hs-CRP and IL-6 levels in the two groups were lower than before treatment. The indexes of the experimental group were (1.02±0.21)ng/mL, (120.26±19.47)pmol/L, (8.33±1.45)mg/L, (11.25±2.71)pg/mL, lower than (1.45±0.24)ng/mL,(219.68±22.51)pmol/L, (16.92±2.70)mg/L, (20.07±4.62)pg/mL in the control group, the differences were statistically significant (P<0.05). Conclusion: For patients with acute cerebral hemorrhage, Chinese herbal medicine for activating blood stasis have good clinical efficacy, can reduce inflammation and improve serum S100β, NT-proBNT levels, it is safety and worthy of clinical application. |
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