| 曾旦丹,赵迎春,朱莹莹,蔡怡子,黄绮薇.新生儿缺氧缺血性脑病血清UA、Cys C及TNF-α水平变化及与脑损伤的相关性研究[J].现代生物医学进展英文版,2018,(14):2665-2668. |
| 新生儿缺氧缺血性脑病血清UA、Cys C及TNF-α水平变化及与脑损伤的相关性研究 |
| Neonatal Hypoxic-ischemic Encephalopathy: Changes of Serum UA, Cys C and TNF-α Levels and Their Correlation with Brain Injury |
| Received:February 28, 2018 Revised:March 21, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.14.013 |
| 中文关键词: 新生儿缺氧缺血性脑病 脑损伤 尿酸 胱抑素C 肿瘤坏死因子-α 相关性 |
| 英文关键词: Neonatal hypoxic-ischemic encephalopathy Brain injury Uric acid Cystatin C Tumor necrosis factor-α Correlation |
| 基金项目:上海市科学技术委员会科研计划项目（12411952562） |
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| 中文摘要: |
| 摘要 目的：研究新生儿缺氧缺血性脑病（NHIE）血清尿酸（UA）、胱抑素C（Cys C）及肿瘤坏死因子-α（TNF-α）水平变化及与脑损伤的相关性。方法：选择从2015年1月到2017年9月在上海市儿童医院接受治疗的NHIE患儿60例纳入观察组，其中急性期42例，恢复期18例；严重程度：轻度26例，中度21例，重度13例。另选同期在我院进行健康体检的新生儿60例作为对照组，检测并对比两组及观察组疾病不同时期、不同严重程度患儿血清UA、Cys C、TNF-α水平、新生儿神经行为评估（NBNA）评分，分析NHIE患儿的NBNA评分与其血清UA、Cys C、TNF-α水平的相关性。结果：观察组的血清UA、Cys C及TNF-α水平均高于对照组，而NBNA评分低于对照组（P<0.05）。观察组急性期患儿的血清UA、Cys C及TNF-α水平均高于恢复期，而NBNA评分低于恢复期（P<0.05）。中度和重度患儿的血清UA、Cys C及TNF-α水平均高于轻度患儿，且重度患儿高于中度患儿，而中度和重度患儿的NBNA评分低于轻度患儿，且重度患儿低于中度患儿（P<0.05）。根据Spearman法分析可知，NHIE患儿的NBNA评分与其血清UA、Cys C、TNF-α水平之间均呈负相关（P<0.05）。结论：NHIE患儿的血清UA、Cys C及TNF-α水平较高，且三者随着脑损伤病情严重程度呈升高的趋势，而NBNA评分则呈降低趋势，三者与NBNA评分互成负向联系，临床上可加以重点关注。 |
| 英文摘要: |
| ABSTRACT Objective: To study the changes of serum uric acid (UA), cystatin C (Cys C) and tumor necrosis factor-α (TNF-α) levels in neonatal hypoxic-ischemic encephalopathy (NHIE) and their correlation with brain injury. Methods: A total of 60 newborns with NHIE, who were treated in Shanghai Children's Hospital from January 2015 to September 2017, were chosen as observation group. Among them, there were 42 cases in the acute stage and 18 cases in the recovery stage; severity degree: 26 cases were mild, 21 cases were moderate, and 13 cases were severe. Another 60 newborns, who underwent physical examination in this hospital during the same period, were selected as control group. The levels of serum UA, Cys C, TNF-α and neonatal neurobehavioral assessment (NBNA) score in the two groups and at different disease stages and different disease severity degree in the observation group were detected and com- pared, and the correlation between NBNA score and serum UA, Cys C, TNF-α levels in the newborns with NHIE was analyzed. Results: The serum levels of UA, Cys C and TNF-α in the observation group were significantly higher than those in the control group, but the NBNA score was significantly lower than that in the control group (P<0.05). The levels of serum UA, Cys C and TNF-α in the acute stage of the observation group were higher than those in the recovery stage, while the NBNA score was lower than that in the recovery stage (P<0.05). The levels of serum UA, Cys C and TNF-α in moderate and severe newborns were higher than those in mild newborns, and severe newborns were higher than those in moderate newborns, while NBNA scores in moderate and severe newborns were lower than those in mild newborns, and severe newborns were lower than those in moderate newborns (P<0.05). According to the analysis of Spearman method, there was a negative correlation between the NBNA score and the levels of serum UA, Cys C, TNF-α in newborns with NHIE (P<0.05). Conclusion: The levels of serum UA, Cys C and TNF-α in newborns with NHIE are higher, and the three are in- creased with the severity of brain injury, while the NBNA score is reduced, the three and the NBNA score are negatively related to each other, which can be paid more attention to in the clinical application. |
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