| 陈邵旻,胡 玲,邓浩华,胡红兵,刘松梅.2型糖尿病患者代谢清除率与血清游离脂肪酸的相关性[J].现代生物医学进展英文版,2018,(13):2465-2468. |
| 2型糖尿病患者代谢清除率与血清游离脂肪酸的相关性 |
| Correlation of Metabolic Clearance Rate with Serum Nonesterified Fatty Acid Level of Type 2 Diabetes Patients |
| Received:March 06, 2018 Revised:March 28, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.13.013 |
| 中文关键词: 2型糖尿病 代谢清除率 游离脂肪酸 |
| 英文关键词: Type 2 diabetes mellitus Metabolic clearance rate Nonesterified fatty acid |
| 基金项目:国家自然科学基金项目（81271919，81472023) |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病(type 2 diabetes mellitus，T2DM)患者代谢清除率(metabolic clearance rate，MCR)与血清游离脂肪酸(nonesterified fatty acid，NEFA)、甘油三酯(triglyceride，TG)和胆固醇的相关性。方法：选择2014年10月至2016年12月我院收治的127例T2DM患者，测量患者身高、体重，并计算身体质量指数(BMI)，进行口服糖耐量试验、胰岛素释放试验，检测血清脂质的水平。将T2DM患者按MCR值分为低MCR组(63例)、高MCR组(64例)，比较两组间临床指标的差异，评价MCR、HOMA-IR与变量间的相关性。结果：T2DM患者BMI、TG、空腹血糖和糖化血红蛋白(HbA1C)均高于参考值；T2DM患者低MCR组HbA1C、空腹血糖、总胆固醇(total cholesterol, TC)、TG、低密度脂蛋白胆固醇(LDL-C)和NEFA明显升高(P＜0.05)，高密度脂蛋白胆固醇(HDL-C)明显降低(P＜0.05)；相关分析显示：MCR与HDL-C呈显著正相关(P＜0.05，r=0.215)，与TC、TG、LDL-C、HbA1C、NEFA均呈显著负相关(P＜0.05；r=-0.191，-0.380，-0.216，-0.587，-0.356)。结论：2型糖尿病患者MCR降低，与HbA1C与血清NEFA水平呈负相关。MCR不仅能评价胰岛素抵抗，而且能反映机体糖脂代谢水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of metabolic clearance rate (MCR) with serum nonesterified fatty acid (NEFA), triglyceride (TG) and cholesterol of patients with type 2 diabetes mellitus (T2DM). Methods: The body mass index (BMI), oral glucose tolerance, insulin release, and fasting serum lipids were determined in 127 cases of T2DM patients from October, 2014 to December, 2016. T2DM patients were divided into the low-MCR group (n=63) and the high-MCR group (n=64) according to MCR median. The clinical characteristics were compared between two groups and the correlations of MCR, HOMA-IR and variables were evaluated. Results: Our data suggested that BMI, TG, fasting glucose and HbA1C of T2DM patiensts were higher than the upper limit of corresponding reference interval. Low-MCR group showed decreased high density lipoprotein cholesterol (HDL-C) and increased fasting glucose, HbA1C, total cholesterol (TC), TG, low density lipoprotein cholesterol (LDL-C) and NEFA (P＜0.05) . MCR was positively correlated with HDL-C (P＜0.05, r=0.215) and negatively correlated with TC, TG, LDL-C, HbA1C, NEFA (P＜0.05; r=-0.191, -0.380,-0.216, -0.587, -0.356). Conclusion:: The MCR of T2DM patients was decreased and negatively correlated with HbA1C and serum NEFA levels. MCR can not only evaluate the insulin resistance, but also reflect the level of glucose and lipid metabolism. |
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