| 金 鑫,李树锦,陈 贞,杨善峰,严 波,金 娟.胃功能三项联合Hp抗体对胃癌及癌前病变的鉴别诊断价值[J].现代生物医学进展英文版,2018,(12):2388-2391. |
| 胃功能三项联合Hp抗体对胃癌及癌前病变的鉴别诊断价值 |
| Differential Diagnosis of Gastric Cancer and Precancerous Lesions with Three Combined Hp Antibodies with Gastric Function |
| Received:November 13, 2017 Revised:November 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.12.040 |
| 中文关键词: 胃功能三项 Hp抗体 胃癌 癌前病变 鉴别诊断 |
| 英文关键词: Gastric function three Hp antibody Gastric cancer Precancerous lesions Differential diagnosis |
| 基金项目:国家自然科学基金项目（30672011）；安徽省自然科学基金项目（050430902）；安徽省人才开发基金项目（2005Z040） |
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| 中文摘要: |
| 摘要 目的：探讨胃功能三项联合幽门螺杆菌(Hp)抗体对胃癌及癌前病变的鉴别诊断价值。方法：收集我院2014年5到2017年8月收治的胃癌患者34例(胃癌组)、癌前病变患者46例(癌前病变组)，抽取研究对象空腹静脉血5 mL，采用酶联免疫吸附法(ELISA)检测血清胃蛋白酶原-I(PG-I)、血清胃蛋白酶原-II(PG- II)，并计算PG-I/ PG- II（PGR）值，采用胶体金法或胶乳免疫比浊法检测HP抗体，比较两组胃功能三项及HP抗体阳性率差异，分析胃功能三项联合HP抗体鉴别诊断价值。结果：胃癌组血清PG-Ⅰ和PGR水平低于癌前病变组(P<0.05)，胃癌组与癌前病变组血清PG-Ⅱ水平、HP抗体阳性率比较差异无统计学意义(P>0.05)。胃癌组HP抗体阳性者和阴性者血清PG-Ⅰ、PG-Ⅱ、PGR水平比较差异均无统计学意义(P>0.05)，癌前病变组HP抗体阳性者血清PG-Ⅰ水平明显低于HP抗体阴性者，差异具有统计学意义(P<0.05)。并联检查胃癌和癌前病变的准确度分别为67.6%(23/34)、43.5%(20/46)，高于串联的14.7%(5/34)、6.5%(3/46)，差异具有统计学意义(P<0.05)。结论：Hp感染可能导致PG-Ⅰ降低，具有癌前病变风险，再降低可能具有胃癌风险，临床上根据胃功能三项筛检早期胃癌并且辅助HP检测可早期诊断胃癌。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the differential diagnosis of gastric cancer and precancerous lesion by three functions of Helicobacter pylori (Hp). Methods: 34 cases of patients with gastric cancer (gastric cancer group), 46 cases of patients with precancerous lesion were selected in this study. The levels of pepsinogen-I (PG-I), pepsinogen- II (PG-II) were detected by enzyme-linked immunosor- bent assay (ELISA). And PG-I/PG-II（PGR）value was calculated. HP antibody was detected by colloidal gold or latex immuno-turbidi- metric method. Three factors and the positive rates of HP antibody were compared between the two groups. The differential diagnosis value of three gastric functions combined HP antibodies was analyzed. Results: The levels of PG-I and PGR of gastric cancer group were lower than those of the gastric precancerous lesion group (P<0.05). There was no significant difference between the two groups in the positive rates of HP antibody and PG-II level (P>0.05). There was no significant difference in the PG-I, PG-II and PGR levels between patients with HP antibody positive and patients with HP antibody negative in gastric cancer group (P>0.05). The level of PG-I of patients with HP antibody positive was lower than patients with HP antibody negative in gastric precancerous lesion group (P<0.05). The accura- cy rate of parallel examination of gastric cancer and precancerous lesions was 67.6%、43.5% respectively, which was higher than the 14.7 % series, 6.5 % series (P<0.05). Conclusion: Hp infection may lead to the decrease of PG-Ⅰ, the risk of precancerous lesion, the possi- ble risk of gastric cancer, the early screening of gastric cancer according to the three functions of gastric cancer, and the diagnosis of gas- tric cancer. |
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