| 马巧亚,何 娅,王锐利,胡春婷,李 琛.丁苯酞软胶囊对急性脑梗死患者ROS、T-AOC、炎症因子及神经功能的影响[J].现代生物医学进展英文版,2018,(12):2306-2310. |
| 丁苯酞软胶囊对急性脑梗死患者ROS、T-AOC、炎症因子及神经功能的影响 |
| Effect of Butylphthalide Soft Capsules on the ROS, T-AOC, Inflammatory Factors and Neurological Function of Patients with Acute Cerebral Infarction |
| Received:November 12, 2017 Revised:December 08, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.12.022 |
| 中文关键词: 丁苯酞 急性脑梗死 活性氧 总抗氧化能力 炎症因子 NHISS评分 |
| 英文关键词: Butylphthalide Acute cerebral infarction Reactive oxygen species Total antioxidant capacity Inflammatory factors NHISS score |
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| 中文摘要: |
| 摘要 目的：探讨丁苯酞软胶囊对急性脑梗死患者活性氧（reactive oxygen species, ROS)、总抗氧化能力(total antioxidant capacity, T-AOC)、炎症因子及神经功能的影响。方法：将2016年7月至2017年7月我院收治的急性脑梗死患者100例随机分为对照组(n=50)和观察组(n=50)。对照组患者给予常规对症治疗，观察组患者在对照组的基础上加用丁苯酞软胶囊。两组连续治疗14天后，比较治疗前后两组血清ROS、T-AOC、炎症因子水平及神经功能的变化及治疗后两组的临床疗效。结果：治疗前，两组血清ROS、T-AOC、高敏C反应蛋白(high sensitive C reaction protein, hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor, TNF-α)、白细胞介素-6(interleukin-6, IL-6)水平、美国国立卫生研究院卒中量表(National Institute of Health stroke scale)评分比较差异均无统计学意义(P>0.05)。与本组治疗前比较，两组治疗后血清T-AOC水平显著升高，且观察组显著高于对照组(P<0.05)；对照组治疗后血清ROS水平显著高于治疗前(P<0.05)，观察组患者治疗前后的血清ROS水平相比差异无统计学意义(P>0.05)，且观察组治疗后ROS水平显著低于对照组(P<0.05)；两组血清hs-CRP、TNF-α、IL-6水平、NHISS评分均显著低于治疗前(P<0.05)，且观察组以上指标均显著低于对照组(P<0.05)；观察组总有效率为82%，明显优于对照组的52%(P<0.05)。结论：在常规治疗的基础上加用丁苯酞软胶囊可有效降低急性脑梗死患者血清炎症因子水平，提高机体总抗氧化能力，促进神经功能的修复，提高临床治疗效果。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of butylphthalide soft capsules on the generation of ROS, T-AOC, inflammatory factors, and neurological function of patients with acute cerebral infarction. Methods: 100 cases of acute cerebral infarction patients in our hospital were randomly divided into the control group (n=50) and the observation group (n=50), patients in the control group was given conventional thraphy, whie the observation group was treated with butylphthalide soft capsules based on the control group. Both groups were given sustainable treatment for 14 days, the levels of serum ROS, T-AOC, inflammatory factors and neurological function were compared before and after treatment. Results: The levels of ROS, T-AOC, hs-CRP, TNF-α, IL-6, NHISS score in both groups showed no statistically significant difference before treatment(P>0.05). Compared with before treatment, the T-AOC levels of both groups were sig- nificantly increased after treatment (P<0.05), and which was significantly higher in the observation group than that of the control group after treatment(P<0.05); the ROS level in control group was significantly higher after treatment than that in the same group before treat- ment(P<0.05), which showed no significant difference in the observation group before and after treatment, and the level of ROS in the observation group was significantly lower than that in the control group after treatment(P<0.05). After treatment, the levels of serum hs-CRP, TNF-α, IL-6 and NHISS score in the two groups were significantly lower than those in the same group before treatment (P<0.05), the above indexes in the observation group were significantly lower than those in the control group (P<0.05). The total effective rate was 82% in the observation group, which was significantly better than 52% in the control group(P<0.05). Conclusion: On the basis of conventional treatment, the addition of butylphthalide soft capsules could effectively reduce the levels of serum inflammatory factors and ROS, improve the total antioxidant capacity, promote the recovery of neurological function. |
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