| 冯 凯,韩 猛,王心妹,李金玲,吴梓政.非哺乳期乳腺炎发病高危因素的病例-对照研究[J].现代生物医学进展英文版,2018,(11):2190-2193. |
| 非哺乳期乳腺炎发病高危因素的病例-对照研究 |
| Case Control Study on Risk Factors of Non Puerperal Mastitis |
| Received:August 20, 2017 Revised:September 14, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.11.041 |
| 中文关键词: 非哺乳期乳腺炎 浆细胞性乳腺炎 肉芽肿性乳腺炎 危险因素 |
| 英文关键词: Non-puerperal mastitis Plasma cell mastitis Granulomatous lobular mastitis Risk factor |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：分析非哺乳期乳腺炎的临床特点及发病高危因素。方法：回顾性分析2011年1月至2016年1月秦皇岛市第一医院乳腺外科就诊，经病理确诊的非哺乳期乳腺炎患者110例（病例组）资料，另选取秦皇岛市第一医院体检中心的健康人群110例作为对照组。比较两组研究对象临床特征，并进行单因素及多因素分析。结果：病例组病人临床分型以肿块型（46.36%）为主，初诊主要症状为单纯肿块39例（35.45%），乳房红肿伴肿块37例（33.64%）。两组在生育次数、肥胖、初育年龄、平均哺乳时间、主动/被动吸烟、乳头内陷、失眠/焦虑、服用避孕药、乳头溢液病史方面比较差异有统计学意义（P<0.05）。多因素分析显示乳头内陷（OR=5.29，95%CI 2.12～13.25，P=0.000）、失眠/焦虑（OR=4.20，95%CI 1.68～10.48，P=0.002）为非哺乳期乳腺炎发病高危因素，而生育次数（OR=0.42，95%CI 0.27～0.64，P=0.001）为该病的保护因素。结论：失眠、焦虑及乳头内陷增加该病发病风险，生育次数多可降低该病的发病风险。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical characteristics and risk factors for non-puerperal mastitis. Methods: A total of 110 cases of non-puerperal mastitis, who were confirmed by pathology (case group) during January 2011 to January 2016 in Breast Surgery Department of Qinhuangdao First Hospital, were retrospectively analyzed. In addition, 110 healthy people in the physical examination center of Qinhuangdao First Hospital were selected as control group. The clinical features of the two groups were compared and analyzed by univariate and multivariate analysis. Results: The main clinical symptoms of the patients in the case group was mass type (46.36%), in which, there were 39 cases of simple mass(35.45%) and 37 cases of breast swelling and mass(33.64%). There was statistical significance in the number of births, obesity, age at first child bearing, the average long duration of breast feeding, active/passive smoking, nipple,insomnia/anxiety, oral contraceptive use, nipple discharge disease between the two groups(P<0.05). Multivariate analysis showed that the nipple (OR=5.29, 95%CI 2.12～13.25, P=0.000) and insomnia/anxiety (OR=4.20, 95%CI 1.68～10.48, P=0.002) were the risk factors of non-puerperal mastitis, but the number of births (OR=0.42, 95%CI 0.27～0.64, P=0.001) was the protective factors of the disease. Conclusion: Insomnia, anxiety and nipple increase the risk of the disease, the number of birth can reduce the risk of the disease. |
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