| 饶玉萍,徐玲娟,游 云,崔纪红,游图南,谭向明.玻璃酸钠联合重组牛碱性成纤维细胞生长因子对糖尿病性白内障超声乳化术后泪膜稳定性的影响[J].现代生物医学进展英文版,2018,(11):2176-2180. |
| 玻璃酸钠联合重组牛碱性成纤维细胞生长因子对糖尿病性白内障超声乳化术后泪膜稳定性的影响 |
| Effect of Sodium Hyaluronate Combine with Recombinant Bovine Basic Fibroblast Growthfactor on Tear Film Stability after Phacoemulsification in Diabetic Cataract |
| Received:September 29, 2017 Revised:October 22, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.11.038 |
| 中文关键词: 玻璃酸钠 重组牛碱性成纤维细胞生长因子 白内障 糖尿病 泪膜 |
| 英文关键词: Sodium hyaluronate Recombinant bovine basic fibroblast growth factor Cataract Diabetes mellitus Tear film |
| 基金项目:湖北省卫计委重点项目（WJ2015MA0416） |
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| 中文摘要: |
| 摘要 目的：探讨玻璃酸钠联合重组牛碱性成纤维细胞生长因子（bFGF）对糖尿病性白内障超声乳化术后泪膜稳定性的影响。方法：选取2015年1月到2017年1月期间在我院接受治疗的150例糖尿病性白内障患者，根据随机数字表法分为对照组和研究组，各75例。两组均进行常规治疗，在常规治疗的基础上对照组采用玻璃酸钠滴眼液进行治疗，研究组在对照组的基础上加用bFGF眼用凝胶进行治疗，两组均治疗1个月。比较两组术前、术后1周、术后1个月的泪膜破裂时间（BUT）、基础泪液分泌试验（SIt）值、角膜荧光素染色（FL）评分、干眼症状评分和眼表疾病指数（OSDI）评分，并比较两组术前、术后1个月的最佳矫正视力。结果：术后1周，两组患者的BUT明显低于术前和术后1个月，且研究组的BUT高于对照组（P<0.05）；随时间推移两组患者的OSDI评分持续降低（P<0.05），术后1周，两组患者干眼症状评分、SIt值、FL评分明显高于术前和术后1个月，且研究组的OSDI评分、干眼症状评分、SIt值、FL评分均低于对照组（P<0.05）。术后1个月两组患者的最佳矫正视力均明显上升，且研究组明显高于对照组（P<0.05）。结论：玻璃酸钠联合bFGF能有效提升糖尿病性白内障患者在超声乳化术后泪膜稳定性，利于患者术后视力的恢复，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of sodium hyaluronate combine with recombinant bovine basic fibroblast growthfactor (bFGF) on tear film stability after phacoemulsification in diabetic cataract. Methods: 150 patients with diabetic cataract who were treated in our hospital from January 2015 to January 2017 were treated. The patients were divided into the control group and the study group by random number table, each with 75 cases. Routine treatment was performed in the two groups, the control group was treated with sodium hyaluronate eye drops on the basis of routine treatment, the study group was treated with bFGF eye gel on the basis of the control group, the two groups were treated for 1 month.The break-up time (BUT), Schirmer test (SIt), corneal fluorescein staining (FL) score, symptoms of dry eye and ocular surface disease index (OSDI) score were compared between the two groups preoperation,1 week after operation and 1 month after operation, and the best corrected visual acuity was compared between the two groups preoperation and 1 month after operation. Results: The BUT of the two groups was significantly lower at 1 week after operation than that at preoperation and 1 month after operation, and the BUT in the study group was higher than that in the control group (P<0.05). The OSDI scores of the two groups continued to decrease over time (P<0.05). The dry eye symptom score, SIt value and FL score of the two groups 1 week after operatio were significantly higher than those at preoperation and 1 month after operation, and the OSDI score, dry eye symptom score,SIt value and FL score of the study group were lower than those of the control group (P<0.05). The best corrected visual acuity of the two groups increased significantly 1 month after operation, and the study group was significantly higher than that of the control group (P<0.05). Conclusion: Sodium hyaluronate combine with bFGF can effectively improve the tear film stability of patients with diabetic cataract after phacoemulsification, and it can beneficial to the recovery of postoperative visual acuity, which is worthy of clinical application. |
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