| 刘丽君,伍于斌,陈 伟,潘宏彬,屈 妍,谢淑芸,胡玉宝.不同剂量辛伐他汀联合曲美他嗪对慢性心力衰竭患者血脂及血清IL-6、TNF-α、BNP水平的影响[J].现代生物医学进展英文版,2018,(11):2171-2175. |
| 不同剂量辛伐他汀联合曲美他嗪对慢性心力衰竭患者血脂及血清IL-6、TNF-α、BNP水平的影响 |
| Chronic Heart Failure: Effects of Different Doses of Simvastatin plus Trimetazidine on Blood Lipid and Serum IL-6, TNF-α and BNP Levels |
| Received:January 10, 2018 Revised:February 28, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.11.037 |
| 中文关键词: 辛伐他汀 曲美他嗪 慢性心力衰竭 血脂 炎性因子 |
| 英文关键词: Simvastatin Trimetazidine Chronic heart failure Blood lipids Inflammatory factors |
| 基金项目:广西壮族自治区医药卫生科研基金项目（Z2011608） |
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| 中文摘要: |
| 摘要 目的：探讨不同剂量辛伐他汀联合曲美他嗪对慢性心力衰竭（CHF）患者血脂及血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、脑钠肽（BNP）水平的影响，为临床用药提供参考。方法：研究对象为2015年1月至2016年6月我院收治的146例CHF患者，将其根据随机数字表法分为两组，其中对照组（n=73）采用常规剂量辛伐他汀（20 mg/d）联合曲美他嗪治疗，观察组（n=73）采用强化剂量辛伐他汀（40 mg/d）联合曲美他嗪治疗，两组均治疗6个月。观察两组疗效，同时测定并比较治疗前后两组患者心功能指标、血脂指标以及炎性因子的变化情况。结果：观察组总有效率为94.52%，明显高于对照组的82.19%（P<0.05）。治疗后,观察组的LVEF明显高于对照组，而LVEDD、LVESD明显低于对照组（P<0.05）。治疗后,观察组的TC、TG、LDL-C、IL-6、TNF-α、BNP水平明显低于对照组，而HDL-C水平明显高于对照组（P<0.05）。两组均无严重不良反应发生。结论：与常规剂量比较，强化剂量辛伐他汀（40 mg/d）联合曲美他嗪治疗CHF具有更好的疗效，对心功能、血脂及炎性因子有更好的改善作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different doses of simvastatin combined with trimetazidine on blood lipid and serum Interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α) and brain natriuretic peptide (BNP) levels in patients with chronic heart failure (CHF), so as to provide references for clinical medication. Methods: A total of 146 CHF patients, who were treated in Guilin People's Hospital from January 2015 to June 2016, were selected and randomly divided into two groups. The control group (n=73) was treated with conventional dose (20 mg/d) simvastatin combined with trimetazidine,while the observation group (n=73) was treated with intensive dose (40 mg/d) simvastatin combined with trimetazidine. The two groups were treated for 6 months. The effects of the two groups were observed and the changes of cardiac function index, blood lipid index and inflammatory factors were measured and compared in the two groups before and after treatment. Results: The total effective rate(94.52%) of the observation group wass significantly higher than that (82.19%) of the control group (P<0.05). After treatment,the LVEF of the observation group was significantly higher than that of the control group, while the LVEDD and LVESD were significantly lower than those of the control group (P<0.05). After treatment, the levels of TC, TG, LDL-C, IL-6, TNF-α and BNP in the observation group were significantly lower than those in the control group, while the HDL-C level was significantly higher than that of the control group (P<0.05). There was no serious adverse reaction in the two groups. Conclusion: Compared with routine dose, intensive dose simvastatin (40 mg/d) combined with trimetazidine in the treatment of CHF has better effect, which has better effect on cardiac function, blood lipid and inflammatory factors. |
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