| 彭玲玲,段婷婷,陈艳焦,王 宇,徐玉东,杨永清,尹磊淼.细胞因子在重症哮喘发病机制中的研究进展[J].现代生物医学进展英文版,2018,(10):1990-1995. |
| 细胞因子在重症哮喘发病机制中的研究进展 |
| The Progress of Cytokines in the Pathogenesis of Severe Asthma |
| Received:December 26, 2017 Revised:January 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.10.039 |
| 中文关键词: 重症哮喘 细胞因子 中性粒细胞 治疗 |
| 英文关键词: Severe asthma Cytokines Neutrophil Treatment |
| 基金项目:国家自然科学基金项目(81473760;81574058)；上海市人才发展基金项目(201610) |
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| 中文摘要: |
| 摘要：重症哮喘是指在过去一年中超过50 %的时间需要给予高剂量糖皮质激素联合长效?茁2-受体激动剂和白三烯调节剂或全身激素治疗，才能维持哮喘控制或即使在上述治疗下仍不能有效控制症状的疾病。重症哮喘发病机制复杂，危险因素多，治疗困难，是临床热点和难点问题。免疫介导的炎症反应在重症哮喘疾病发生中处于重要地位，多种炎症细胞和前炎性因子介导的免疫应激均参与了重症哮喘的发生和发展。本综述对细胞因子的表达与重症哮喘炎症病理改变做了分析，有助于深入研究重症哮喘发病机制，以期为临床诊断和寻找更为有效的靶向治疗药物提供新的理论依据和策略。 |
| 英文摘要: |
| ABSTRACT: Severe asthma refers to more than six months in one year, high-dose glucocorticoid combined with long-acting ?茁2-ag- onists and leukotriene modulators or systemic corticosteroid therapy are given to control asthma, or still could not control effectively with the above treatment. It is a clinical hot and difficult issues due to its complex pathogenesis, multiple risk factors, difficult treatment. In- flammatory cells and pro-inflammatory factors involve in the occurrence and development of severe asthma, as a result, immune-medi- ated inflammatory injury plays an important role in the severe asthma. The expression levels of cytokines in the severe asthma and its pathological changes are analyzed in this review, which will be beneficial to further study the pathogenesis with the purpose of provid- ing new theoretical basis and strategy for clinical diagnosis and more effective targeted therapy drugs. |
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