| 陈丰穗,张世安,吴志贤,张 霞,曾芝雨,周晓玲,李东良.血清B7-H4水平对肝细胞癌的诊断及预后价值[J].现代生物医学进展英文版,2018,(10):1960-1964. |
| 血清B7-H4水平对肝细胞癌的诊断及预后价值 |
| Diagnostic and Prognostic Prediction Value of Serum B7-H4 Level for Hepatocellular Carcinoma |
| Received:November 10, 2017 Revised:December 07, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.10.032 |
| 中文关键词: 肝细胞癌 预后 诊断 B7-H4分子 |
| 英文关键词: Hepatocellular carcinoma Prognosis Diagnosis Serum B7-H4 |
| 基金项目:福建省科技联合创新基金项目(2016Y9063)；福建省自然科学基金面上项目(2016J01583)；中国博士后基金第59批（2016M590597）；福建省科技厅引导性项目(2015Y5007) |
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| 中文摘要: |
| 摘要 目的：探讨肝细胞癌(HCC)患者血清B7-H4水平及其临床意义。方法：采用ELISA方法检测和比较116例HCC患者和60例健康对照人群的血清B7-H4水平，并分析血清B7-H4水平和HCC患者临床参数和生存情况的关系。结果：①HCC患者的血清B7-H4水平显著高于健康对照组(P<0.001)；②血清B7-H4水平与HCC患者血清AFP水平(r=0.653, P=0.012)和TNM分期(r=0.713, P=0.003)相关；③高血清B7-H4组HCC患者5年总体生存率较低血清B7-H4组显著降低(P=0.028)；④血清B7-H4水平是HCC预后的独立预测因子(P=0.034)。结论：HCC患者的血清B7-H4水平显著上调，对于HCC的诊断及预后判断具有重要的参考意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the serum B7-H4 level of hepatocellular carcinoma (HCC) patients and its clinical signifi- cance. Methods: The serum B7-H4 level wase detected and compared in 116 cases of patients with HCC and 60 healthy controls by ELISA, and the relationships between serum B7-H4 levels and clinical parameters and the survival of HCC patients were analyzed. Results: HCC patients had significantly higher serum B7-H4 level as compared with the healthy controls(P<0.001); the serum B7-H4 level was correlated with the clinical parameters of HCC patients including the serum AFP level (r=0.653, P=0.012) and TNM stage(r=0.713, P=0.003); HCC patients with higher B7-H4 level group had a poorer 5-year overall survival rate (P=0.028). Moreover, the serum B7-H4 level was shown to be an independent prognostic factor for HCC(P=0.034). Conclusion: The serum B7-H4 level of HCC patients was signifi- cantly increased, which had important value for the diagnosis and prognosis of HCC. |
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