| 李诚博,程笑晨,刘晨光.海藻酸钠漂浮微囊的制备以及载药应用研究[J].现代生物医学进展英文版,2018,(10):1833-1841. |
| 海藻酸钠漂浮微囊的制备以及载药应用研究 |
| Preparation and Drug Loading Application of Sodium Alginate Floating Microcapsules |
| Received:July 28, 2017 Revised:August 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.10.007 |
| 中文关键词: 海藻酸钠 漂浮微囊 药物递送系统 包埋 |
| 英文关键词: Alginate Floating microcapsule Drug delivery system, Encapsulation |
| 基金项目:山东省科技发展计划资助项目（2015GGE29028） |
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| 中文摘要: |
| 摘要 目的：本文研究了一种海藻酸钠漂浮微囊的制备方法用以实现胃部持续给药。方法：采用微胶囊发生器制备海藻酸钠漂浮微囊，壁材为海藻酸钠，芯材为食用油的漂浮微囊，衡量不同的制备参数对微囊的理化特性影响；采用克拉霉素作为模型脂溶性药物，测量漂浮药物递送系统的控制释放性质、以及微囊载药特性和小鼠体内漂浮验证。结果：成功制备出了具有漂浮特性的海藻酸钠微囊，其中泵送速度对微囊性质的影响最大。制备出的微囊具有低细胞毒性，可以实现90%的药物包埋率。此外，微囊可以在小鼠的胃中保存超过6小时，具有良好的漂浮特性。结论：海藻酸钠漂浮微囊是一种有效的胃部药物递送系统，可明显延长药物在胃部的滞留时间。 |
| 英文摘要: |
| ABSTRACT Objective: In this paper, a sodium alginate floating microcapsules was prepared to achieve the goal of sustained admin- istration in the stomach. Methods: The microcapsules, which had the outer layer of alginate and inner layer of oil, were prepared by a kind of microcapsule generator. The effects of different preparation parameters on the physical and chemical properties of microcapsules were investigated. Moreover, the controlled release properties of floating drug delivery system using clarithromycin as model liposoluble drugs was determined. In the end, the drug loading efficiency and floating test were also carried out. Results: The alginate microcapsules with floating characteristics were successfully prepared, and the pumping speed had the greatest effect on the microcapsule properties. The prepared microcapsules can achieve 90% drug efficiency which has low cytotoxicity. In addition, the microcapsules can be stored in the stomach of mice for more than 6 hours which meant great floating properties. Conclusion: Sodium alginate floating microcapsules are effective gastric drug delivery system that can significantly prolong the retention time of the drug in the stomach. |
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