| 田 彬,郝贺玲,杨丹丹,高胜利,徐 珞.Orexin-A对大鼠胃功能的影响[J].现代生物医学进展英文版,2018,(9):1633-1636. |
| Orexin-A对大鼠胃功能的影响 |
| Effects of Orexin-A on the Stomach Function of Rats |
| Received:May 28, 2017 Revised:June 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.09.007 |
| 中文关键词: Orexin-A 迷走神经复合体 胃运动 胃液 |
| 英文关键词: Orexin-A DVC Gastric motility Gastric fluid |
| 基金项目:国家自然科学基金项目（81470815,81270460,81500414）；山东省优秀中青年科学基金项目（BS2014YY009）；青岛市科技局项目（14-2-3-3-nsh） |
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| 中文摘要: |
| 摘要 目的：探讨Orexin-A对大鼠胃功能的影响。方法：通过大鼠迷走神经复合体微量注射Orexin-A后，观察大鼠胃运动、胃液和胃酸分泌的变化。结果：DVC微量注射Orexin-A后，大鼠胃收缩幅度以及收缩频率明显升高，且呈明显剂量依赖关系(P<0.05)，SB334867可显著阻断Orexin-A对促胃运动效应(P＜0.05)。DVC微量注射orexin-A后，大鼠胃液及胃酸分泌且呈剂量依赖性增加(P<0.05)。结论：迷走神经复合体微量注射Orexin-A能影响胃的运动以及胃内体液的分泌。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of microinjection of orexin-A into vagal complex (DVC) on the gastric function of rats. Methods: Orexin-A was microinjected into the DVC, the changes of gastric motility and gastric juice or gastric acid secretion were observed. Results: After the microinjection of orexin-A into DVC, the amplitude and frequency of gastric motility were significantly increased in a dose-dependent manner. SB334867 prevented Orexin-A-induced changes of gastric motility(P<0.05). After the microinjec- tion of orexin-A into DVC, the secretion of gastric juice and gastric acid were significantly increased in a dose-dependent manner (P<0.05). Conclusion: Orexin-A could affect gastric motility and the secretion of gastric fluid. |
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