| 王 萌,蒋红利,何 荃,史珂慧,刘 华,薛瑾虹.血液透析联合血液灌流治疗对慢性肾衰竭患者肾功能、微炎症状态和血液净化效果的影响[J].现代生物医学进展英文版,2018,(8):1511-1514. |
| 血液透析联合血液灌流治疗对慢性肾衰竭患者肾功能、微炎症状态和血液净化效果的影响 |
| Effect of Hemodialysis Combined with Hemoperfusion on Renal Function,Micro Inflammatory State and Blood Purification Effect in Patients with Chronic Renal Failure |
| Received:December 23, 2017 Revised:January 18, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.08.022 |
| 中文关键词: 血液透析 血液灌流 慢性肾衰竭 肾功能 微炎症状态 血液净化 |
| 英文关键词: Hemodialysis Hemoperfusion Chronic renal failure Renal function Micro inflammatory state Blood purification |
| 基金项目:陕西省社会发展科技攻关项目（2016SF-239） |
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| 中文摘要: |
| 摘要 目的：探讨血液透析（HD）联合血液灌流（HP）治疗对慢性肾衰竭（CRF）患者肾功能、微炎症状态和血液净化效果的影响。方法：选取2015年3月-2017年3月期间我院收治的CRF患者90例作为研究对象，采用随机数字表法分为对照组（n=45）和研究组（n=45），对照组在常规治疗的基础上给予HD治疗，研究组在对照组治疗的基础上给予HD联合HP治疗，对比两组治疗前后的肾功能、微炎症状态、血液净化效果。结果：治疗后研究组肌酐清除率（Ccr）较对照组增加，血尿氮（BUN）、血肌酐（Cr）较对照组下降（P<0.05）。治疗后研究组白细胞介素（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）水平较对照组下降（P<0.05）。治疗后研究组同型半胱氨酸（Hcy）、甲状旁腺激素（PTH）及β2-微球蛋白（β2-MG）水平较对照组下降（P<0.05）。研究组总不良反应发生率为4.44%（2/45），低于对照组的15.56%（7/45）（P<0.05）。结论：HD联合HP治疗CRF，能够有效改善患者肾功能和炎症反应，清除肾脏内的有毒物质，从而提升血液净化效果，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of hemodialysis (HD) combined with hemoperfusion (HP) on renal function,micro inflammation state and blood purification in patients with chronic renal failure (CRF). Methods: 90 patients with CRF admitted in our hospital from March 2015 to March 2017 were selected as the subjects. They were divide into the control group (n=45) and the study group (n=45) by random number table methods. The control group was treated with HD on the basis of routine treatment.The study group was given HD combined with HP on the basis of treatment in the control group. The renal function,the micro inflammation state and the blood purification effect before and after the treatment were compared. Results: After treatment, the creatinine clearance (Ccr) in the study group was increased compared with the control group,the blood urine nitrogen (BUN) and the creatinine (Cr) were lower than those in the control group (P<0.05). After treatment, the levels of interleukin (IL-6), C reactive protein (CRP) and tumor necrosis factor-α (TNF-α) in the study group were lower than those in the control group (P<0.05). After treatment, the levels of homocysteine (Hcy), parathyroid hormone (PTH) and β2-microglobulin (β2-MG) in the study group were lower than those in the control group (P<0.05). The incidence of total adverse reactions in the study group was 4.44% (2/45), which was lower than 15.56% in the control group (7/45) (P<0.05). Conclusion: HD combined with HP in the treatment of CRF can effectively improve the renal function and inflammatory reaction, remove toxic substances in the kidneys, and improve the effect of blood purification, and the safety is good. |
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