| 刘丽丹,吴春林,贺 漪,黄浩梁,朱一麟.血清间皮素联合CDK6诊断早期卵巢癌的临床价值研究[J].现代生物医学进展英文版,2018,(8):1506-1510. |
| 血清间皮素联合CDK6诊断早期卵巢癌的临床价值研究 |
| Clinical Value of Serum Albumin Combined with CDK6 in the Diagnosis of Early Ovarian Cancer |
| Received:October 19, 2017 Revised:November 13, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.08.021 |
| 中文关键词: 血清间皮素 CDK6 CA125 早期卵巢癌诊断 |
| 英文关键词: Serum mesothelin CDK6 CA125 Early ovarian cancer Diagnosis |
| 基金项目:国家自然科学基金青年基金项目(81402125) |
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| 中文摘要: |
| 摘要 目的：探讨血清间皮素联合CDK6诊断早期卵巢癌的临床价值。方法：选择2014年6月～2017年6月就诊于我院妇产科的51例Ｉ~Ⅱ期卵巢癌患者(实验组)及同期经病理确诊为正常卵巢组织的43例患者(对照组)为研究对象，检测和比较其血清MSLN、CA125、CA199、HE4、VEGF-C水平及卵巢癌组织CDK6的表达。采用多因素logistic回归进一步分析两种间上述有显著差异的指标。同时，对新指标与血清CA125、CA199水平进行相关性分析，ROC曲线分析其对早期卵巢癌的诊断价值。结果：实验组血清MSLN、CA125、CA199、HE4、VEGF-C水平及CDK6表达均显著高于对照组(P＜0.05)。多因素logistic分析结果显示血清MSLN、CA125、CDK6表达对早期卵巢癌的诊断有价值(P<0.05)，且血清CA125的影响程度最高(RR=1.421)。卵巢癌患者血清MSLN(r=0.573，P=0.013)和卵巢癌组织CDK6表达(r=0.412，P=0.037)与CA125呈正相关关系。ROC曲线提示血清MSLN、CDK6表达、血清CA125及MSLN联合CDK6诊断早期卵巢癌的ROC曲线下面积分别为0.639、0.700、0.715、0.765，MSLN联合CDK6的曲线下面积最大。结论：血清MSLN联合癌组织CDK6的表达诊断早期卵巢癌的临床价值明显优于常规血清学指标CA125、CA199。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical value of serum mesothelin conbined with CDK6 in the diagnosis of early ovarian cancer. Methods: 51 cases of patients who were diagnosed as stage I ~ Ⅱ ovarian cancer (experimental group) in the department of obstetrics and gynecology of our hospital from June 2014 to June 2017 and 43 cases of patients with normal ovarian tissue were diagnosed by pathology(control group) and selected as the research object. The serum MSLN, CA125, CA199, HE4, VEGF-C levels and CDK6 expression of ovarian tissue were detected and compared. The significantly different indicators between the two groups were further analyzed by multifactor logistic regression. At the same time, the correlative analysis between the new index and the serum CA125, CA199 levels were carried out, the diagnostic value for early ovarian cancer was analyzed by ROC curve. Results: The serum MSLN, CA125, CA199, HE4, VEGF-C levels and CDK6 expression of experimental group were significantly higher in the experimental group than those of the control group (P<0.05). Multifactor logistic regression showed that serum MSLN, CA125 levels and CDK6 expression were valuable in the diagnosis of early ovarian cancer (P<0.05), and the serum CA125 had the highest impact(RR=1.421). The serum MSLN level of ovarian cancer patients(r=0.573, P=0.013) and the CDK6 expression of the Ovarian tissue (r=0.412，P=0.037) were positively correlated with serum CA125 level. ROC curves indicated that the area of the ROC curve of serum MSLN, CDK6 expression, serum CA125 and MSLN combined with CDK6 were 0.639, 0.700, 0.715 and 0.765, The area under the curve of MSLN combined with CDK6 was the highest. Conclusion: The clinical value of serum MSLN combined with CDK6 expression in the ovarian cancer tissue for the diagnosis of early ovarian cancer was superior to the conventional serological index CA125, CA199. |
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