| 李 爽,李 丽,魏力军,吴 琼,李炳生.氧化损伤和微重力致骨质疏松症的研究进展[J].现代生物医学进展英文版,2018,(7):1376-1379. |
| 氧化损伤和微重力致骨质疏松症的研究进展 |
| Research Progress of the Oxidative Injury and Microgravity Induced Osteoporosis |
| Received:May 21, 2017 Revised:June 15, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.07.039 |
| 中文关键词: 微重力 氧化损伤 骨质疏松 Nrf2 |
| 英文关键词: Micro-gravity Oxidative damage Osteoporosis Nrf2 |
| 基金项目:国家自然科学基金项目（11474076） |
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| 中文摘要: |
| 摘要：伴随着人口老龄化日益严重，骨质疏松症作为"悄无声息的流行病"逐渐引起人们的注意。氧化损伤和力学刺激是造成骨质疏松的两个主要原因。一方面氧化损伤可通过刺激FoxOs信号通路抑制成骨细胞分化，造成骨质疏松，另一方面机体在长期缺乏负荷力刺激时也会发生废用性骨丢失，二者之间存在着紧密的联系。Nrf2作为细胞应对氧化损伤的主要防御机制，可调控多种抗氧化蛋白酶转录，在氧化损伤所造成的骨质疏松中扮演着重要角色。本文综述了氧化损伤和微重力造成骨质疏松的机制以及Nrf2对抗氧化损伤的调节和对修复骨质发育的影响。 |
| 英文摘要: |
| ABSTRACT: With growing an aging population, the osteoporosis, also called "silent epidemic" has been paid more and more atten- tion. Both oxidative damage and mechanical stimulation are the main reasons to induce osteoporosis. On the one hand, the oxidative damage can lead to osteoporosis by stimulating FoxOs signals to inhibit osteoblast differentiation, on the other hand, the disuse bone loss can also occur due to lack of load force stimuli with time. There is a close correlation between them. Nrf2 is a main defense mechanism against oxidative damage in cells, which can control various antioxidant protease transcription and plays an important role in the osteo- porosis caused by oxidative damage. In this paper, we will review the mechanism of the microgravity and oxidative damage to cause the osteoporosis. The Nrf2 how to regulate and control the oxidative damage, as well as the effects on rehabilitating the bone development is also introduced. |
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