| 张玉龙,孙 颖,胡丽娜,姚小青,马静维.不同严重程度支气管哮喘患者血清LXA4水平的表达及临床意义[J].现代生物医学进展英文版,2018,(7):1360-1363. |
| 不同严重程度支气管哮喘患者血清LXA4水平的表达及临床意义 |
| Expression and Clinical Significance of Serum LXA4 Levels in Patients with Different Severity of Bronchial Asthma |
| Received:May 16, 2017 Revised:June 12, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.07.035 |
| 中文关键词: 支气管哮喘 血清脂氧素A4 表达 临床意义 |
| 英文关键词: Bronchial asthma Serum lipoprotein A4 Expression Clinical significance |
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| 中文摘要: |
| 摘要 目的：探讨不同严重程度支气管哮喘患者血清脂氧素A4（LXA4）水平的表达及临床意义。方法：选取我院2015年10月到2016年11月收治的支气管哮喘患者86例作为研究组，另选同期我院体检结果为健康的40例志愿者纳入正常对照组，根据病情的不同严重程度将研究组分为轻度持续组（26例）、中度持续组（36例）、重度持续组（24例）。比较正常对照组和研究组患者的血清LXA4水平，比较研究组不同严重程度的第1s用力呼气量占预计值的百分比（FEV1%），并分析支气管哮喘患者的LXA4水平与FEV1%的相关性。结果：轻度持续组、中度持续组、重度持续组和正常对照组血清中LXA4水平整体比较差异有统计学意义（P<0.05）；中度持续组血清中LXA4水平显著高于轻度持续组、重度持续组和正常对照组，重度持续组血清中LXA4水平显著高于轻度持续组和正常对照组，轻度持续组血清中LXA4水平显著高于正常对照组，差异有统计学意义（P<0.05）；轻度持续组、中度持续组、重度持续组的FEV1%整体比较差异有统计学意义（P<0.05）；重度持续组的FEV1%显著低于轻度持续组和中度持续组，中度持续组的FEV1%显著低于轻度持续组，差异有统计学意义（P<0.05）；经Spearman统计分析，支气管哮喘患者的LXA4水平与FEV1%呈明显的负相关（r=-0.486，P=0.041）。结论：LXA4在支气管哮喘中度持续患者血清中表达最高，在轻度持续患者血清中表达最低，支气管哮喘越严重FEV1%水平越低，同时LXA4水平与FEV1%呈明显的负相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of serum lipoprotein A4 (LXA4) levels in patients with different severity of bronchial asthma. Methods: A total of 86 patients with bronchial asthma, who were admitted to Baoji Traditional Chinese Medicine Hospital of Shaanxi Province from October 2015 to November 2016, were chosen as study group; 40 healthy volun- teers were included in control group during the same period. According to the severity of the disease, the study group was further divided into mild persistent group (n=26), moderate persistent group (n=36), severe persistent group (n=24). The serum LXA4 levels were com- pared between the control group and the study group. The percentage of forced expiratory volume as estimated at 1s (FEV1%) at the dif- ferent severity levels in the study group was compared. The correlation between LXA4 and FEV1% in patients with bronchial asthma was analyzed. Results: There were significant differences in the serum LXA4 levels among the mild persistent group, moderate persistent group, severe persistent group and control group (P<0.05); the serum LXA4 levels in moderate persistent group were significantly higher than those in mild persistent group, severe persistent group and control group; the serum LXA4 levels in the severe persistent group was significantly higher than those in the mild persistent group and the control group; the serum LXA4 levels in the mild persistent group was significantly higher than that in the control group, the differences were statistically significant (P<0.05). There were significant differ- ences in FEV1% among mild persistent group, moderate persistent group and severe persistent group (P<0.05); FEV1% in the severe per- sistent group was significantly lower than those in the mild persistent group and the moderate persistent group; FEV1% in the moderate persistent group was significantly lower than that in mild persistent group, the differences were statistically significant (P<0.05). Spear- man analysis showed that there was a significant negative correlation between LXA4 and FEV1% (r=-0.486, P=0.041) in patients with bronchial asthma. Conclusion: LXA4 is the highest expressed in the serum of patients with moderate persistent bronchial asthma, but it is the lowest expressed in the serum of patients with mild persistent bronchial asthma. The more severe the bronchial asthma is, the lower the FEV1% level is; at the same time, the LXA4 level is negatively correlated with FEV1%. |
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