| 宋红勇,刘东屏,王 宏,郭广洋,何俊鹏.CD133、β-catenin在胃癌组织中的表达与临床意义[J].现代生物医学进展英文版,2018,(7):1352-1355. |
| CD133、β-catenin在胃癌组织中的表达与临床意义 |
| Expressions and Clinical Significances of CD133, β-catenin in the Gastric Cancer |
| Received:September 08, 2017 Revised:September 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.07.033 |
| 中文关键词: 胃癌 CD133 β-catenin 临床特征 淋巴结转移 浸润深度 |
| 英文关键词: Gastric cancer CD133 β-catenin Clinical features Lymph node metastasis Depth of invasion |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨胃癌组织CD133、β-catenin的表达与临床意义。方法：分别选择2013年12月到2017年2月选择在我院进行诊治的胃癌患者标本120例和同期在我院收治的正常胃组织标本120例作为观察组和对照组，采用免疫组化检测CD133、β-catenin表达情况，并分析CD133、β-catenin的表达与胃癌患者临床病理特征的相关性。结果：观察组与对照组CD133、β-catenin阳性表达率分别为75.0 %和63.3 %，均明显高于对照组[3.3 %和9.7 %](P<0.05)。CD133、β-catenin的表达与胃癌的浸润深度、淋巴结转移、黏液癌、Dukes分期呈正相关(P<0.05)，与肿瘤的分化程度呈负相关(P<0.05)。结论：CD133、β-catenin的表达上调可能参与了胃癌的发生与发展，并可能作为胃癌诊断和预后预测的参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expressions and significances of CD133, β-catenin in the gastric cancer. Methods: From August 2013 to February 2017, 120 cases of gastric cancer tissue and the other 120 cases of normal gastric tissue specimens in our hospi- tal were selected as the observation group and control group at the same period respectively, immunohistochemical analysis was per- formed to detect the expression of CD133, β-catenin, and the correlation of CD133, β-catenin expression with the clinicopathologic fea- tures of gastric cancer were analyzed. Results: The positive expression rates of CD133, β-catenin in the observation group were 75.0 % and 63.3 % respectively, which were significantly higher than those of the control group[3.3 % and 9.7 %](P<0.05). The expression of CD133, β-catenin in gastric cancer were positively correlated to the depth of invasion, lymph node metastasis, mucinous carcinoma, Dukes stage (P<0.05), and were negatively correlated with the degree of tumor differentiation (P<0.05). Conclusion: Up regulation of CD133, β-catenin expressions may be involved in the occurrence and development of gastric cancer, which could be used as reference index in the diagnosis and prognostic prediction of gastric cancer. |
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