| 尚 华,张德芬,何 芳,汪佳利,陈 龙.糖皮质激素联合吗替麦考酚酯分散片对系统性红斑狼疮患者的疗效及对免疫功能的影响[J].现代生物医学进展英文版,2018,(7):1326-1329. |
| 糖皮质激素联合吗替麦考酚酯分散片对系统性红斑狼疮患者的疗效及对免疫功能的影响 |
| Clinical Efficacy of Glucocorticoid Combined with Mycophenolate Mofetil Capsules in Treatment of Systemic Lupus Erythematosus and Its Effect on Immune Function |
| Received:May 10, 2017 Revised:June 06, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.07.027 |
| 中文关键词: 糖皮质激素 吗替麦考酚酯分散片 系统性红斑狼疮 免疫指标 |
| 英文关键词: Glucocorticoid Mycophenolate mofetil dispersion tablets Systemic lupus erythematosus Immunological index |
| 基金项目:四川省卫生厅科研资助项目（N2006-ZC00402） |
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| 中文摘要: |
| 摘要 目的：研究糖皮质激素联合吗替麦考酚酯分散片治疗系统性红斑狼疮患者的临床疗效及对免疫功能的影响。方法：选取2014年9月至2015年8月本院收治的84例系统性红斑狼疮患者，根据投硬币法分为观察组和对照组，42例每组。对照组使用单纯的糖皮质激素，观察组在此基础上使用吗替麦考酚酯分散片。比较两组患者临床疗效，治疗前后免疫球蛋白A(IgA)、免疫球蛋白(IgG)、免疫球蛋白(IgM)、C反应蛋白(CRP)、血沉(ESR)的变化及不良反应的发生情况。结果：治疗后，观察组临床总有效率显著高于对照组(P<0.05)。治疗前，两组患免疫球蛋白A(IgA)、免疫球蛋白(IgG)、免疫球蛋白(IgM)、C反应蛋白(CRP)、血沉(ESR)水平比较差异均无统计学意义(P>0.05)；治疗后，两组患者IgA、IgG、IgM、CRP、ESR水平均较治疗前显著降低(P<0.05)，与对照相比，观察组的IgA、IgG、IgM、CRP、ESR明显降低(P<0.05)。两组组的不良反应率比较差异无统计学意义(P>0.05)。结论：糖皮质激素联合吗替麦考酚酯分散片能有效改善系统性红斑狼疮患者的免疫功能，临床疗效良好，安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of glucocorticoid combined with mycophenolate mofetil tablets on the systemic lupus erythematosus and its effect on the immune function. Methods: Forty-eight patients with systemic lupus erythematosus treated ad- mitted in our hospital from September 2014 to August 2015 were randomly divided into the observation group and the control group. The control group was treated by glucocorticoid alone, and the observation group was given mycophenolate tablets on the basis of control group. The levels of immunoglobulin A (IgA), immunoglobulin (IgG), immunoglobulin (IgM), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and the occurrence of adverse effects were compared between two groups before and after treatment. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group (P<0.05). Before treat- ment, there was no significant difference in the immunotherapy (IgA), immunoglobulin (IgG), immunoglobulin (IgM), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) between the two groups (P <0.05). After treatment, the levels of IgA, IgG, IgM, CRP and ESR in the two groups were significantly lower than those before treatment (P<0.05). Compared with the control group, IgA, IgG, IgM, CRP and ESR in the observation group were lower (P<0.05). There was no significant difference in the adverse reaction rate between two groups (P>0.05). Conclusion: Glucocorticoids combined with mycophenolate mofetil dispersion tablets could effectively improve the im- mune function of patients with systemic lupus erythematosus with high safety. |
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