| 刘林海,汪 勇,张 仰,郭 钏,王 俊.宁泌泰胶囊联合盐酸莫西沙星治疗慢性前列腺炎患者的临床疗效及对血清TNF-α、IL-1β、M-CSF的影响[J].现代生物医学进展英文版,2018,(7):1318-1321. |
| 宁泌泰胶囊联合盐酸莫西沙星治疗慢性前列腺炎患者的临床疗效及对血清TNF-α、IL-1β、M-CSF的影响 |
| Curative Efficacy of Ningmitai Capsule Combined with Moxifloxacin Hydrochloride in Treatment of Chronic Prostatitis and Its Effects on Serum Levels of TNF-α, IL-1β and M-CSF |
| Received:May 28, 2017 Revised:June 22, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.07.025 |
| 中文关键词: 慢性前列腺炎 宁泌泰胶囊 盐酸莫西沙星 肿瘤坏死因子-α 白介素-1β 巨噬细胞集落刺激因子 |
| 英文关键词: Chronic prostatitis Ningmitai capsule Moxifloxacin hydrochloride Tumor necrosis factor-α Interleukin-1β Macrophage colony stimulating factor |
| 基金项目:四川省卫生厅科研基金项目(09011) |
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| 中文摘要: |
| 摘要 目的：探讨宁泌泰胶囊联合盐酸莫西沙星治疗慢性前列腺炎患者的临床疗效及对血清肿瘤坏死因子(TNF)-α、白介素(IL)-1β、巨噬细胞集落刺激因子(M-CSF)水平的影响。方法：选择2014年8月至2016年8月我院接诊的110例慢性前列腺炎患者，通过随机数表法分为观察组(n=55)和对照组(n=55)。对照组采用盐酸莫西沙星治疗，观察组联合宁泌泰胶囊治疗，均连续治疗2周。比较两组治疗前后慢性前列腺炎症状评分(NIH-CPSI)、前列腺液白细胞计数、血清TNF-α、IL-1β、M-CSF水平的变化及临床疗效。结果：治疗后，观察组临床疗效总有效率明显高于对照组(P＜0.05)；两组NIH-CPSI评分、白细胞计数、血清TNF-α、IL-1β、M-CSF均较治疗前显著降低(P＜0.05)，观察组以上指标均明显低于对照组(P＜0.05)。结论：宁泌泰胶囊联合盐酸莫西沙星治疗慢性前列腺炎的临床效果显著，可有效缓解临床症状，安全性高，其机制可能和降低血清TNF-α、IL-1β、M-CSF水平相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of ningmitai capsule combined with moxifloxacin hydrochloride in the treat- ment of chronic prostatitis and its effects on the serum tumor necrosis factor(TNF)-α, interleukin(IL)-1β and macrophage colony stimu- lating factor(M-CSF) levels. Methods: 110 patients of chronic prostatitis who were treated from August 2014 to August 2016 in our hos- pital were selected and divided into the observation group (n=55) and the control group (n=55) according to the random number table. The control group was treated with moxifloxacin hydrochloride, while the observation group was treated by ningmitai capsule on the ba- sis of control group. All the patients were treated for 2 weeks. The changes of chronic prostatitis symptom score (NIH-CPSI), white blood cell count, serum TNF-α, IL-1β and M-CSF levels and the clinical efficacy were compared between the two groups before and after treat- ment. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group(P＜0.05); the NIH-CPSI scores of pain, urination disorder and quality of life, white blood cell count, serum TNF-α, IL-1β and M-CSF levels of both groups were significantly lower than those before treatment(P＜0.05), which were significantly lower in the observation group than those of the control group(P＜0.05). Conclusion: Ningmitai capsule combined with moxifloxacin hydrochloride was effective for chronic prostatitis, it could effectively relieve the clinical symptoms with high safety, which might be related to the decrease of serum TNF-α, IL-1β and M-CSF levels. |
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