| 王 祥,屈功奇,戴太强,邵小夕,杨林元,刘 斌,刘彦普.新型可降解锌合金内固定系统用于犬下颌骨骨折固定的研究[J].现代生物医学进展英文版,2018,(7):1234-1238. |
| 新型可降解锌合金内固定系统用于犬下颌骨骨折固定的研究 |
| A Study on a New Type of Biodegradable Zinc Alloy Internal Fixation System for Mandibular Fracture Fixation in Dogs |
| Received:October 13, 2017 Revised:October 31, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.07.007 |
| 中文关键词: 锌 合金 可降解 骨折固定术 下颌骨 |
| 英文关键词: Zinc Alloy Biodegradable Fracture Fixation Mandible |
| 基金项目:军队十二五重点基金项目（BWS11JO46） |
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| 中文摘要: |
| 摘要 目的：探讨新型可降解锌合金内固定系统用于犬下颌骨骨折固定的可行性。方法：选择比格犬12只，并将其随机分为两组，其中6只为锌合金实验组，6只为钛合金对照组。每只比格犬的下颌作左右两个骨折内固定模型，每侧骨折模型使用一套小型四孔直连内固定产品。分别于术后即刻、术后4周、12周拍X片。于术前、术后4周、12周、24周抽血检测微量元素锌。于术后12周、24周分批次将动物安乐死，取下颌骨块行Micro-CT检测，取动物重要脏器和内固定周围软组织做病理切片。结果：全程动物无脱落，实验组与对照组骨折均临床愈合。X线图像及Micro-CT显示实验组与对照组的内固定效果比较差异无统计学意义(P>0.05)。锌合金表面有明显的降解产物，Micro-CT测量锌合金的板钉初始体积为155.8±1.536 mm3，12周体积为147.1±0.9893 mm3，24周体积为137±5.365 mm3，降解率12.07%，随着植入后时间的延长显著下降(P<0.05)，而钛合金板钉体积无显著变化。实验组及对照组心、肝、肾及植入物板周软组织均未见异常。血清锌离子浓度在正常范围内略有上升，各时间节点比较差异无统计学意义(P>0.05)。结论：可降解锌合金内固定系统可以对犬下颌骨骨折提供稳固的固定，可降解锌合金在下颌骨部位具有一定的降解性能，血液中锌离子未见明显异常升高，对心、肝、肾及植入物周围软组织无毒性作用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the feasibility of internal fixation system prepared by the new biodegradable zinc alloy for the fixation of mandibular fractures in dogs. Methods: Twelve beagle dogs were selected and randomly divided into two groups with 6 cases in each group, zinc alloy experimental group and titanium alloy control group. Each beagle dog mandibular made of left and right fracture fixation model, each side of the fracture model was treated by a small four-hole direct internal fixation products. The radiographs was taken immediately after operation, at 4 weeks and 12 weeks after operation. Zn content in blood plasma was measured preoperation, at 4 weeks, 12 weeks and 24 weeks after operation. Animals were euthanized at 12 weeks and 24 weeks. Micro-CT was performed on the mandible of canine. The vital organs of animals and the soft tissue surrounding the internal fixation were used for pathological sections. Results: The animals in experimental group and control group were clinically healed. X-ray images and Micro-CT showed no significant difference in the effect of fixation between two groups(P>0.05). Zinc alloy surface showed obvious degradation products. The initial volume of zinc alloy plate and nails measured with Micro-CT was 155.8±1.536 mm3, the volume at 12 weeks was 147.1±0.9893 mm3, the volume at 24 weeks was 137±5.365 mm3, the degradation rate was 12.07%, which decreased significantly with the prolongation of time after implantation(P<0.05), while the volume of titanium alloy plate and nails showed no significant change. There was no abnormalities in the soft tissue of heart, liver, kidney and soft tissue surrounding the internal fixation in the experimental group and the control group. Serum zinc ion concentration in the normal range of a slight increase, there was no significant difference between each time point(P>0.05). Conclusion: Degradable zinc alloy internal fixation system can provide a solid fixation for canine mandibular fractures. Degradable zinc alloy has a certain degradation performance in the mandible of the canine. There was no significant abnormally high in- crease in zinc concentration in the blood. Degradable zinc alloy has no toxic effect on the heart, liver, kidney and the soft tissue surround- ing the internal fixation. |
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