| 桑丽平,郑栋栋,郎元君,刘云章,卢 玲.高迁移率族蛋白成员HMG20a/b的研究进展[J].现代生物医学进展英文版,2018,(5):997-1000. |
| 高迁移率族蛋白成员HMG20a/b的研究进展 |
| Research Progress of HMG20a/b, Members of High Mobility Group Proteins |
| Received:June 27, 2017 Revised:July 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.05.046 |
| 中文关键词: 高迁移率族蛋白 HMG20a/b HMG-box LSD1-CoREST |
| 英文关键词: High Mobility Group proteins HMG20a/b HMG-box LSD1-CoREST |
| 基金项目:国家自然科学基金委与山东省人民政府联合资助海洋科学研究中心项目（U1406402） |
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| 中文摘要: |
| 摘要：高迁移率族（HMG）蛋白是一类广泛存在的非组蛋白型染色体蛋白，能通过诱导染色质结构的变化影响DNA表达。HMG20a和HMG20b是一对高度同源的HMG家族蛋白，均含有一个结构保守的HMG-box结构域和一个coiled-coil结构域，在生物体内广泛表达。HMG20a/b在细胞核内参与组蛋白去甲基酶复合物LSD1-CoREST的形成及一系列与细胞分裂分化相关的生理进程，如神经细胞核红细胞的分化、细胞质分裂以及EMT过程。研究发现，HMG20a/b一些功能的发挥是通过LSD1-CoREST复合物来实现的；在神经分化过程中，HMG20a、HMG20b具有相互拮抗的作用；而HMG20a促进EMT过程反映它很可能是一个促癌因子。本文对HMG20a/b的结构和体内分布及生物学功能进行综述。 |
| 英文摘要: |
| ABSTRACT: High Mobility Group (HMG) proteins are a class of widespread non-histone chromosomal proteins, which impact DNA expression by inducing structure changes in chromatin. HMG20a and HMG20b are close paralogues of HMG family proteins, both with a conserved HMG-box domain and a coiled-coil domain, and are widely expressed in vivo. They are involved in the formation of histone demethylase complex LSD1-CoREST in the nucleus and participate in a series of physiological processes associated with cell division and differentiation, such as neuronal and erythrocyte differentiation, cytoplasmic cleavage, and EMT processes. Researches suggest that several functions of HMG20a/b are achieved by LSD1-CoREST complexes. The antagonistic effects between HMG20a and HMG20b are observed during neural differentiation, while HMG20a is confirmed to promote the EMT process, which reflects that it is probably a cancer-inducing factor. The structure and in vivo distribution as well as biological functions of HMG20a/b are reviewed in this paper. |
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