| 鄢英男,李 琳,孙夕林,车舒平,申宝忠.磁共振功能成像在监测乳腺癌新辅助化疗中的应用和进展[J].现代生物医学进展英文版,2018,(5):979-981. |
| 磁共振功能成像在监测乳腺癌新辅助化疗中的应用和进展 |
| Function Magnetic Resonance: Monitoring Response to Chemotherapy in Breast Cancer |
| Received:March 08, 2017 Revised:March 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.05.041 |
| 中文关键词: 乳腺癌 磁共振功能成像 新辅助化疗 |
| 英文关键词: Breast cancer MRI NAC |
| 基金项目:国家重点基础发展规划项目（973项目）（2015CB931800）；国家自然科学基金重点项目（81130028）；黑龙江省科技攻关重大项目（GA12C302） |
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| 中文摘要: |
| 摘要：近年来，新辅助化疗在原发乳腺癌治疗中运用越来越广泛。影像学手段在评价新辅助化疗疗效、指导临床治疗方案的制定中发挥重要作用。磁共振功能成像的引入，可以加深对恶性乳腺肿瘤的病理生理活动及分子生物学特性的了解，监测化疗疗效，提高早期预测的准确性。本文总结功能学MRI（磁共振成像）探测乳腺癌患者生物标志物的研究现状及发展情况，描述各种生物学标志物特性，评价其潜在的临床应用价值和局限性。以下将对动态增强磁共振成像、弥散加权成像、血氧水平依赖成像以及波谱成像等几种磁共振功能学成像方法的原理进行描述，重点对其在监测乳腺癌新辅助化疗中的应用进行综述。 |
| 英文摘要: |
| ABSTRACT: Recently, neoadjuvant chemotherapy is used in women with primary breast malignancies increasingly. The effects of imaging techniques on eminating response to NAC and establishing clinical dosage plans are important. Functional MR techniques can provide new sight to detect pathophysiological and biomolecular processes in breast malignance lesions. We describe the characteristics of various biomarkers detected by function MR and evaluate their potential clinical application value and limitations. This article summa- rizes principle of several function magnetic resonance techniques (DCE-MRI, DWI-MRI, BOLD, MRS) and focuses on the application of these techniques in monitoring the response to chemotherapy. |
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