| 李 燕,王艺淳,曾兰瑶,彭 科,黄 亮.寻常型银屑病患者血清IL-17、IL-18、VEGF的表达及与病情严重程度的相关性研究[J].现代生物医学进展英文版,2018,(5):960-963. |
| 寻常型银屑病患者血清IL-17、IL-18、VEGF的表达及与病情严重程度的相关性研究 |
| The Expression of Serum IL-17, IL-18 and VEGF in Patients with Psoriasis Vulgaris and its Correlation Study with the Severity of the Disease |
| Received:June 16, 2017 Revised:June 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.05.036 |
| 中文关键词: 寻常型银屑病 白介素17 白介素18 血管内皮生长因子 |
| 英文关键词: Psoriasis vulgaris IL-17 IL-18 VEGF |
| 基金项目:四川省卫生厅基金资助项目（19027293） |
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| 中文摘要: |
| 摘要 目的：探讨寻常型银屑病患者血清白介素17（IL-17）、白介素18（IL-18）、血管内皮生长因子（VEGF）的表达及与病情严重程度的相关性。方法：选取2015年8月到2017年4月在我院接受治疗的寻常型银屑病患者86例为研究组，另选取同期在我院体检结果为健康的志愿者40例作为健康对照组，并根据临床症状和病情变化对研究组患者进行分组，其中进行期银屑病组32例，静止期银屑病组24例，退行期银屑病组30例。对比研究组和健康对照组血清中IL-17、IL-18、VEGF水平，对比不同严重程度的寻常型银屑病患者血清中IL-17、IL-18、VEGF水平和PASI评分，采用Spearman相关性分析IL-17、IL-18、VEGF的表达与PASI评分的相关性。结果：研究组患者血清中的IL-17、IL-18、VEGF水平显著高于健康对照组（P<0.05），进行期银屑病组患者血清中IL-17、IL-18、VEGF水平和PASI评分显著高于静止期银屑病组和退行期银屑病组，静止期银屑病组患者血清中IL-17、IL-18、VEGF水平和PASI评分显著高于退行期银屑病组（P<0.05），Spearman相关性分析结果显示，研究组患者血清中IL-17、IL-18、VEGF水平与PASI评分均呈正相关（P<0.05）。结论：寻常型银屑病患者血清中IL-17、IL-18、VEGF水平异常升高，且其水平与病情严重程度有关，对上述三种指标进行监测有助于临床治疗寻常型银屑病。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of serum interleukin 17 (IL-17), interleukin 18 (IL-18) and vascular endothe- lial growth factor (VEGF) in patients with psoriasis vulgaris and its correlation study with the severity of the disease. Methods: 86 pa- tients with psoriasis vulgaris treated in our hospital from August 2015 to April 2017 were selected as the study group. In addition, 40 healthy volunteers in our hospital were selected as the healthy control group during the same period. The patients in the study group were grouped according to the clinical symptoms and the changes of their condition, they were divided into progressive stage psoriasis group (n=32), quiescent stage psoriasis group (n=24) and degenerative stage psoriasis group (n=30). The levels of serum IL-17, IL-18 and VEGF were compared between the study group and the healthy control group. The levels of serum IL-17, IL-18, VEGFand PASI score were compared in patients with different subgroups in study group. Analyzed the correlation between the expression of IL-17, IL-18, VEGF and PASI score by Spearman correlation analysis. Results: The levels of serum IL-17, IL-18 and VEGF in the study group were significantly higher than those in the healthy control group (P<0.05). The levels of serum IL-17, IL-18, VEGF and PASI score in the pro- gressive stage psoriasis grope were significantly higher than those in the quiescent stage psoriasis group and the degenerative stage psori- asis group. The levels of serum IL-17, IL-18, VEGF and PASI score in the quiescent stage psoriasis group were significantly higher than those in the degenerative stage psoriasis group (P<0.05). Spearman correlation analysis showed that, the levels of serum IL-17, IL-18 and VEGF in the study group were positively correlated with the PASI score(P<0.05). Conclusion: The levels of serum IL-17, IL-18 and VEGF are abnormally elevate in patients with psoriasis vulgaris,and their levels are related to the severity of the disease. Monitoring the above three indicators is helpful for the clinical treatment of psoriasis vulgaris. |
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