| 徐 振,何绍明,周 宁,单 鹏,胡 凯.羟考酮注射液对全髋关节置换术患者血清TNF-α、IL-6、IL-2水平及镇痛效果的影响[J].现代生物医学进展英文版,2018,(5):919-922. |
| 羟考酮注射液对全髋关节置换术患者血清TNF-α、IL-6、IL-2水平及镇痛效果的影响 |
| Influence of Oxycodone Injection on Serum TNF-α, IL-6 and IL-2 and Analgesic Effect of Patients with Total Hip Arthroplasty |
| Received:May 12, 2017 Revised:June 09, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.05.026 |
| 中文关键词: 羟考酮注射液 全髋关节置换术 肿瘤坏死因子-α 白介素-6 白介素-2 |
| 英文关键词: Oxycodone injection Total hip arthroplasty Tumor necrosis factor-α Interleukin-6 Interleukin-2 |
| 基金项目:全军十一五医学科研课题基金面上项目(06MA109) |
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| 中文摘要: |
| 摘要 目的：研究羟考酮注射液对全髋关节置换术患者血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、IL-2水平及镇痛效果的影响。方法：选取2015年7月至2016年6月我院收治的84例全髋关节置换术患者，根据患者入院顺序分为观察组和对照组，42例每组。对照组在术后使用硫酸吗啡注射液，观察组在术后使用羟考酮注射液。比较两组患者治疗前后血清TNF-α、IL-6、IL-2水平的变化、镇痛效果、术后主动直腿抬高30°时间、主动外展患肢达45°时间及不良反应的发生情况。结果：治疗后，两组患者血清TNF-α、IL-6、IL-2水平较治疗前显著升高(P<0.05)，但观察组的血清TNF-α、IL-6、IL-2水平明显低于对照组(P<0.05)。术后6、12、24、48、72 h，两组患者的VAS评分均呈不同程度的下降，观察组术后6、12、24、48、72 h明显高于对照组(P<0.05)。治疗后，观察组主动直腿抬高30°时间、主动外展患肢达45°时间显著短于对照组(P<0.05)。此外，观察组总的不良反应率显著低于对照组(P<0.05)。结论：羟考酮注射液对全髋关节置换术患者血清TNF-α、IL-6、IL-2水平的影响较小，且镇痛效果较好，安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the influence of oxycodone injection on the serum levels of tumor necrosis factor-α (TNF-α), in- terleukin-6 (IL-6), interleukin-2(IL-2) and analgesic effect of patients with total hip arthroplasty. Methods: From July 2015 to June 2016, 84 patients with total hip arthroplasty were selected in our hospital and divided into the observation group and the control group. The control group was treated by morphine sulfate injection after the operation. The observation group was treated with oxycodone injection. The levels of serum TNF-α, IL-6 and IL-2 before and after treatment, analgesic effect prolonged by 30 °, active progression of limb limb 45 ° time and the occurrence of adverse reactions were compared between two groups. Results: After treatment, the levels of serum TNF-α, IL-6 and IL-2 in both groups were significantly higher than those before treatment (P<0.05), but the levels of serum TNF-α, IL-6 and IL-2 in the observation group were significantly lower than those of the control group (P<0.05). The VAS scores of both groups were decreased at 6, 12, 24, 48 and 72 hours after operation. The levels of VAS in the observation group were significantly higher than those in the control group at 6, 12, 24, 48 and 72 hours after operation (P<0.05). After treatment, the rats in the observation group were raised by 30 ° , active extubation limb up to 45 ° time was significantly shorter than that of the control group (P<0.05). In addition, the overall adverse reaction rate of observation group was significantly lower than that of the control group (P<0.05). Conclusion: Oxycodone injection showed little effect on the levels of serum TNF-α, IL-6 and IL-2 of patients with total hip arthroplasty with good analgesic effect and high security. |
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