| 康 健,李胜龙,杨金坤,樊拥军,韦有佩.甲泼尼龙琥珀酸钠对外伤性脑水肿患者血清NO、ET、LPO和SOD水平的影响[J].现代生物医学进展英文版,2018,(5):911-914. |
| 甲泼尼龙琥珀酸钠对外伤性脑水肿患者血清NO、ET、LPO和SOD水平的影响 |
| Efficacy of Methylprednisolone Sodium Succinate in the Treatment of Traumatic Brain Edema and effects on the Serum NO, ET, LPO, SOD Levels |
| Received:May 31, 2017 Revised:June 24, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.05.024 |
| 中文关键词: 外伤性脑水肿 甲泼尼龙琥珀酸钠 疗效 一氧化氮 内皮素 过氧化脂质 超氧化物歧化酶 |
| 英文关键词: Traumatic brain edema Methylprednisolone sodium succinate Curative effect Nitric oxide. Endothelin Peroxide Superoxide dismutase |
| 基金项目:江苏省教育厅自然科学基金项目(2003109) |
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| 中文摘要: |
| 摘要 目的：观察甲泼尼龙琥珀酸钠用于治疗外伤性脑水肿的疗效及对患者血清一氧化氮(NO)、内皮素(ET)、过氧化脂质(LPO)、超氧化物歧化酶(SOD)水平的影响。方法：选择我院2014年11月~2016年11月收治的104例外伤性脑水肿患者，按治疗方式分为对照组与研究组，每组52例。对照组采用常规治疗，研究组在对照组基础上联合甲泼尼龙琥珀酸钠治疗，两组均持续治疗7天。观察并比较两组临床疗效，治疗前后血清NO、ET、LPO、SOD水平、脑水肿体积、神经功能缺损程度评分(NIHSS)、格拉斯哥昏迷评分(GCS)的变化及并发症的发生情况。结果：治疗后，研究组的治疗总有效率高于对照组(P<0.05)；两组血清NO、SOD、GCS水平均较治疗前显著上升，且研究组明显高于对照组；两组血清ET、LPO、NIHSS、脑水肿体积均较治疗前明显降低，且研究组显著低于对照组，差异均有统计学意义(P<0.05)。两组并发症的发生情况比较差异无统计学意义(P>0.05)。结论：甲泼尼龙琥珀酸钠可显著提高外伤性脑水肿的临床疗效，可能与其能够有效调节血清NO、ET、LPO、SOD水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the efficacy of methylprednisolone sodium succinate in the treatment traumatic brain edema and effect on the serum nitric oxide (NO), endothelin (ET) and lipid peroxide (LPO) and superoxide dismutase (SOD) levels. Methods: 104 cases of patients with traumatic brain edema from November 2014 to November 2016 were divided into the control group and the re- search group according to the treatment mode, both groups were treated for seven days. The control group was treated with conventional treatment, and the research group was treated with methylprednisolone sodium succinate based on control group. The clinical curative ef- fect, changes of serum NO, ET and LPO, SOD, cerebral edema volume, National Institutes of Health Stroke Scale (NIHSS) and Glasgow coma scale (GCS) before and after the treatment, and incidence of complications were observed and compared between two group. Results: The total effective rate of research group was higher than that of the control group (P<0.05). Before treatment, no significant difference was found in the serum NO, ET, LPO, SOD levels, cerebral edema volume, NIHSS, GCS NO between two groups(P>0.05). After treat- ment, the serum NO, SOD, GCS levels of both group were markedly higher than those of the control group, which were significantly higher in the research group than those of the control group, the serum ET and LPO, NIHSS, cerebral edema volume of both groups were significantly lower than those before treatment, which were significantly lower in the the research group than those of the control group(P<0.05). There was no statistically significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: Prednisolone sodium succinate could effectively enhance the clinical efficacy of traumatic cerebral edema, which might be related to significant regulation of the serum levels of NO, ET, LPO, SOD. |
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