| 齐 晗,张东霞,曹国琴,赵 艳,林 江.骨髓间充质干细胞复合支架材料的骨组织工程研究进展[J].现代生物医学进展英文版,2018,(4):794-796. |
| 骨髓间充质干细胞复合支架材料的骨组织工程研究进展 |
| The Study of Bone Marrow Stem Cells Combined with Scaffolds in Bone Tissue Engineering |
| Received:February 27, 2017 Revised:March 23, 2017 |
| DOI：10.13241/j.cnki.pmb.2018.04.044 |
| 中文关键词: 组织工程 骨髓间充质干细胞 支架材料 |
| 英文关键词: Bone mesenchymal stem cells Bone tissue engineering Scaffold |
| 基金项目:黑龙江省留学归国人员科学基金项目(LC201435) |
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| 中文摘要: |
| 摘要：近年来，组织工程技术飞速发展，将种子细胞与支架材料相复合的骨组织工程研究已成为热点，并日趋走向成熟。这一全新的治疗方案将成为解决临床上各种原因造成的骨组织缺损的最有效途径之一。骨组织工程技术包括种子细胞、支架材料和生长因子三个方面。其中，BMSCs因具有多向分化能力、强大的增殖能力以及低免疫源性被认为是最理想的种子细胞，而支架材料的种类有很多种，目前对支架材料的选择也尚有分歧。如何找到理想的支架材料是骨组织工程研究中亟待解决的重要问题。本文就组织工程中与骨髓间充质干细胞（BMSCs）相复合的各类支架材料的研究现状进行综述，这些支架材料的研究将为骨组织工程支架材料的选择提供有效依据。 |
| 英文摘要: |
| ABSTRACT: In recent years, tissue engineering approaches which combine the use of cultured living cells and scaffolds has become a new focus of research. This new treatment has the potential to become one of the most promising techniques to repair large bone losses. This method consists of three elements: seed cells, carriers and cytokines. Among all of the seed cells, bone marrow stem cells (BMSCs) are widely used in recent research because of its multi-directional capabilities, powerful proliferation and low immunogenic properties. However, as the types of scaffolds are various, there is much debate concerning the effectiveness of each choice. Therefore, search for a ideal scaffold to stimulate bone regeneration has become the most important step in the study of tissue engineering. This review covers recent researches of BMSCs that combine various scaffolds for applications in tissue engineering and tissue regeneration. The materials covered in this review can provide sounding evidence to the selection of optimal solution for tailored tissue engineering scaffolds. |
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